Differential effects of dietary fats on sympathetic nervous system activity in the rat.
Differential effects of dietary fats on sympathetic nervous system activity in the rat.
复制标题
膳食脂肪对大鼠交感神经系统活动的不同影响。
DOI：
10.1016/0026-0495(94)90157-0
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Walgren,MC
中科院分区：
文献类型：
--
作者：
Young,JB;Walgren,MC
脂肪喂养刺激大鼠交感神经系统（SNS）活动。为了确定脂肪作为SNS兴奋剂的效力是否不同，我们测量了在实验饲料中添加红花油、椰子油或中链甘油三酯（MCT）的动物的心脏和肩胛间棕色脂肪组织（IBAT）中[3H]去甲肾上腺素（[3H]NE）的转化。在第5天，所有三种脂肪都加速了心脏中的[3H]NE的转换，并且作用相同，但只有当脂肪补充代表能量摄入增加时。然而，14天后，红花油和椰子油而不是MCT增加了心脏中[3H]NE的周转率，与喂食等量食物的动物相比。此外，红花油对[3H]NE周转的刺激作用在统计学上大于喂食等量椰子油的动物。在抑制多巴胺-β-羟化酶（DβH）后，通过心脏内多巴胺（DA）的积累来评估体内NE的合成，同样在红花油喂养的大鼠中最高，在MCT喂养的大鼠中最低。因此，不同脂肪对交感神经的激活是不同的，这表明脂肪酸摄入在饮食调节SNS中的作用。
Fat feeding stimulates sympathetic nervous system (SNS) activity in rats. To determine if fats vary in their potency as stimulants of the SNS, [3H]norepinephrine ([3H]NE) turnover was measured in heart and interscapular brown adipose tissue (IBAT) of animals fed lab chow diets supplemented with safflower oil, coconut oil, or medium-chain triglycerides (MCT). At 5 days, all three fats accelerated [3H]NE turnover in heart and did so equally, but only when the fat supplement represented an increase in energy intake. However, after 14 days, safflower oil and coconut oil but not MCT increased [3H]NE turnover in heart compared with turnover rates obtained in animals fed isoenergetic amounts of chow. Furthermore, the stimulatory effect of safflower oil on [3H]NE turnover was statistically greater than that seen in animals fed equivalent amounts of coconut oil. In vivo synthesis of NE assessed by accumulation of dopamine (DA) in heart following inhibition of dopamine-β-hydroxylase (DβH) was likewise highest in safflower oil-fed rats and lowest in those fed MCT. Thus, sympathetic activation by dietary fat varies among different fats, suggesting a role for fatty acid intake in dietary regulation of the SNS.