Morning cortisol as a risk factor for subsequent major depressive disorder in adult women
Morning cortisol as a risk factor for subsequent major depressive disorder in adult women
复制标题
DOI：
10.1192/bjp.177.6.505
复制
发表时间：
2000-12-01
影响因子：
10.5
通讯作者：
Herbert, J
中科院分区：
文献类型：
--
作者：
Harris, TO;Borsanyi, S;Herbert, J
背景皮质醇的个体差异是否会导致随后的重度抑郁症（MDD）尚不清楚，目的是确定发病前唾液皮质醇和脱氢表雄酮（DHEA）水平是否与随后的MDD相关，以及这些与已知增加MDD风险的心理社会因素有关。目前没有人抑郁; 83人对MDD“心理社会脆弱”，33人没有。唾液类固醇（皮质醇和DHEA在08.00小时和20.00小时），最近的生活事件，目前的情绪和社会支持进行了评估。在13个月的随访期间记录MDD的发作。结果唾液皮质醇或DHEA与最近的生活事件或脆弱性之间没有关联。随访期间发生28例MDD发作。这与以下方面有关：严重的不良生活事件和困难，在随访期间，平均早晨皮质醇水平在入口处，并存在任何三个脆弱factors.Conclusions早晨唾液皮质醇水平的个体差异可能是一个独立的危险因素，随后MDD。皮质醇的这些差异的起源还不清楚。
Background Whether individual differences in cortisol contribute to subsequent major depressive disorder (MDD) is unknown.Aims To determine whether premorbid levels of salivary cortisol and dehydroepiandrosterone (DHEA) were associated with subsequent MDD and how these related to psychosocial factors known to increase the risk for MDD.Method Adult women (n=116)were recruited from general practices. None was currently depressed; 83 were 'psychosocially vulnerable' to MDD, 33 were not. Salivary steroids (cortisol and DHEA at 08.00 h and 20.00 h), recent life events, current mood and social support were assessed at entry. Onset of MDD was recorded during 13 months' follow-up.Results There were no associations between salivary cortisol or DHEA and recent life events or vulnerability. Twenty-eight onsets of MDD occurred during the follow-up period. This was associated with: severe adverse life events and difficulties during the follow-up period; mean morning cortisol levels at entry; and the presence of any of three vulnerability factors.Conclusions Individual differences in morning salivary cortisol levels may represent an independent risk factor for subsequent MDD. The origin of these differences in cortisol is not yet understood.