Stem Cell Therapy in Lupus.
Stem Cell Therapy in Lupus.
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狼疮的干细胞治疗
DOI：
10.2478/rir-2022-0011
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发表时间：
2022-06
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中科院分区：
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系统性红斑狼疮（SLE）是一种慢性自身免疫性和炎症性疾病，累及多个器官和系统，如肾脏、肺脏、大脑和造血系统。尽管对该疾病发病机制的认识不断增加，治疗方案也有所改进，但目前的免疫抑制疗法未能阻止超过半数接受治疗的患者疾病复发。因此，旨在克服传统治疗的不良事件并提高难治性SLE治愈率的细胞替代疗法被视为一种替代治疗选择。大量动物研究和临床试验表明，干细胞疗法是治疗SLE的一种有前景的治疗方法。自首次应用于人类患者以来，多种干细胞类型已应用于该领域，包括造血干细胞（HSCs）和间充质干细胞（MSCs）。在这篇综述中，我们概述了干细胞的不同细胞来源以及干细胞疗法在治疗SLE中的应用，以及造血干细胞移植（HSCT）和间充质干细胞移植（MSCT）之间的比较。
Systemic lupus erythematosus (SLE) is a chronic autoimmune and inflammatory disease with multiple organs and systems involved such as the kidney, lung, brain and the hematopoietic system. Although increased knowledge of the disease pathogenesis has improved treatment options, current immunosuppressive therapies have failed to prevent disease relapse in more than half of treated patients. Thus, the cell replacement therapy approach that aims to overcome adverse events of traditional treatment and improve recovery rate of refractory SLE is considered as an alternative treatment option. A large number of animal studies and clinical trials have shown stem cell therapy to be a promising therapeutic approach for the treatment of SLE. Since the first transplantation into human patients, several stem cell types have been applied in this field, including hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs). In this review, we overview different cell sources of stem cells and applications of the stem cell therapy for treatment of SLE, as well as the comparison between HSCs transplantation (HSCT) and MSCs transplantation (MSCT).