Disk-Drive-Like Operations in the Hippocampus
Disk-Drive-Like Operations in the Hippocampus
复制标题
海马体中类似磁盘驱动器的操作
DOI：
10.1101/2022.10.05.511000
复制
发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Nicola W
中科院分区：
文献类型：
--
作者：
Nicola W
在海马体中以脉冲序列的形式快速计算可重复播放的记忆是一种接近计算机的操作。信息可以在初始体验中编码一次，然后在压缩时间表示中重播多次[-]。θ波振荡、锐波涟漪和吸引子动力学被认为在记忆的形成和重放中共同发挥作用。然而，这些动态状态之间的确切相互作用仍然难以捉摸。在这里，我们展示了海马体的记忆形成动态和操作不仅仅是类似于计算机，而是直接映射到磁盘驱动器的动态和操作。我们构建了一个三方尖峰神经网络模型，其中海马体被明确描述为带有旋转磁盘、执行器臂和读/写头的磁盘驱动器。在这个神经磁盘驱动器（NDD）模型中，海马体振荡映射到旋转磁盘网络中的磁盘旋转，而致动器臂网络中的吸引子动力学指向磁盘上的“轨迹”（spike assemblies）。读/写头然后将信息写入这些轨道，这些轨道具有时间结构的尖峰。在海马体波纹期间可以重放音轨以巩固记忆。我们在实验数据中证实了由旋转圆盘网络预测的中间神经元环序列的存在。我们的研究结果表明，海马体是一个大脑区域，显示出明确的、类似计算机的操作。基于海马体和其他大脑区域之间已知的相互作用，我们预计我们的结果可能会导致更多的模型，重新审视大脑执行明确的、类似计算机的操作的假设。
The rapid computation of re-playable memories within the hippocampus in the form of spike sequences is a near computer-like operation. Information can be encoded once during the initial experience, and replayed numerous times after in a compressed-time representation [–]. Theta oscillations, sharp-wave ripples, and attractor dynamics have been posited to collectively play a role in the formation and replay of memories. However, the precise interplay between these dynamical states remains elusive. Here, we show that the memory formation dynamics and operations of the hippocampus are not just computer-like, but map directly onto the dynamics and operations of a disk-drive. We constructed a tripartite spiking neural network model where the hippocampus is explicitly described as a disk drive with a rotating disk, an actuator arm, and a read/write head. In this Neural Disk Drive (NDD) model, hippocampal oscillations map to disk rotations in the rotating disk network while attractor dynamics in the actuator arm network point to “tracks” (spike assemblies) on the disk. The read/write head then writes information onto these tracks, which have temporally-structured spikes. Tracks can be replayed during hippocampal ripples for consolidation. We confirmed the existence of interneuron-ring-sequences, predicted by the rotating disk network, in experimental data. Our results establish the hippocampus as a brain region displaying explicit, computer-like operations. Based on the known interactions between the hippocampus and other brain areas, we anticipate that our results may lead to additional models that revisit the hypothesis that the brain performs explicit, computer-like operations.
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影响因子：
2.4
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
McNaughton, Bruce L.
DOI：
--
发表时间：
1989
期刊：
Bio Systems
影响因子：
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作者：
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影响因子：
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作者：
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影响因子：
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作者：
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