Myeloma protein kinetics following chemotherapy.
Myeloma protein kinetics following chemotherapy.
复制标题
化疗后骨髓瘤蛋白动力学。
DOI：
10.1182/blood.v60.4.851.851
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发表时间：
1982
期刊：
影响因子：
20.3
通讯作者：
R. Alexanian
中科院分区：
文献类型：
--
作者：
P. Mclaughlin;R. Alexanian
在 43 名血清和尿液中单克隆球蛋白水平较高的多发性骨髓瘤患者中评估了化疗的效果。在有反应的患者中，本斯·琼斯蛋白排泄比血清骨髓瘤蛋白下降得更快、更显着。在有反应者中，Bence Jones 蛋白排泄在 2 个月内减少了 50%，在无反应者中保持不变，在部分疾病控制的患者中，以 2-7 个月的缓慢减半时间下降。三名具有治疗临床耐药性的患者表现出非典型的蛋白质变化，并且相对于其血清单克隆成分，本斯琼斯蛋白质排泄逐渐增多。 Bence Jones 蛋白排泄的连续测量为多发性骨髓瘤患者的肿瘤质量变化提供了早期且可靠的指标。
The effects of chemotherapy were evaluated in 43 multiple myeloma patients with high monoclonal globulin levels in both serum and urine. In responding patients, Bence Jones protein excretion declined more rapidly and markedly than the serum myeloma protein. Bence Jones protein excretion was reduced by 50% within 2 mo in responders, remained unchanged in nonresponders, and declined with a slow halving time of 2-7 mo in patients with partial disease control. Three patients with clinical resistance to treatment showed atypical protein changes and progressively more Bence Jones protein excretion relative to their serum monoclonal component. Serial measurements of Bence Jones protein excretion provided an early and reliable index of tumor mass change in patients with multiple myeloma.