Development and Long-Term In Vivo Evaluation of a Biodegradable Urethane-Doped Polyester Elastomer
Development and Long-Term In Vivo Evaluation of a Biodegradable Urethane-Doped Polyester Elastomer
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DOI：
10.1002/mame.201100074
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发表时间：
2011-12-12
影响因子：
3.9
通讯作者：
Yang, Jian
中科院分区：
文献类型：
--
作者：
Dey, Jagannath;Tran, Richard T.;Yang, Jian
使用具有4，6，8，10，或12个亚甲基单元的二醇合成的CUPE聚合物的发展的详细报告，提出的目的是阐明二醇组分对所得材料的物理性质的影响，并评估其在体内的长期生物学性能。增加二醇长度导致较低的交联密度、较高的疏水性、较高的拉伸强度和弹性以及较慢的聚合物降解。二醇的选择不影响体外和体内的总体细胞/组织相容性。因此，二醇组分被确立为控制聚合物的结构/性能关系的重要参数，从而增加了用于组织工程应用的可生物降解弹性体的选择。
A detailed report on the development of CUPE polymers synthesized using diols with 4, 6, 8, 10, or 12 methylene units is presented with the aim of elucidating the influence of the diol component on the physical properties of the resulting material and assessing their long-term biological performance in vivo. Increasing the diol length leads to lower crosslinking densities, higher hydrophobicities, higher tensile strengths and elasticities, and slower polymer degradation. The choice of diol does not affect the overall cell/tissue compatibility both in vitro and in vivo. The diol component is thus established as an important parameter in controlling the structure/property relationships of the polymers, thereby increasing the choice of biodegradable elastomers for tissue engineering applications.