Increased interleukin-7 concentrations in lesional skin and in the sera of patients with plaque-type psoriasis
Increased interleukin-7 concentrations in lesional skin and in the sera of patients with plaque-type psoriasis
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DOI：
10.1006/clin.1996.4313
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发表时间：
1997-04-01
期刊：
影响因子：
--
通讯作者：
Ameglio, F
中科院分区：
文献类型：
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作者：
Bonifati, C;Trento, E;Ameglio, F
几种细胞因子已被证明在银屑病中增加，主要在局部，有时在全身水平。目前，银屑病与白细胞介素-7 （IL-7）之间的关系尚无相关资料。这种生物调节剂通过其多形性活性来调节免疫反应，包括刺激不同单核细胞功能的能力，如杀死细胞内病原体、诱导细胞因子和增强某些膜分子的表达。研究组由9名银屑病患者和9名正常人组成。使用市售免疫酶法，测定各种样品中的IL-7浓度：活检和鳞片提取物、外周血单个核细胞（PBMCs）上清液和血清。结果表明，与非病变皮肤和正常皮肤相比，病变皮肤活检和鳞片提取物中IL-7水平显著升高（P至少）
Several cytokines have been shown to be increased in psoriasis, mainly at the local and sometimes at the systemic level. At present, no data concerning the relationships between psoriasis and interleukin-7 (IL-7) are available. This biological modifier regulates immune response by means of its pleomorphic activities, including the ability to stimulate different monocyte functions, such as killing of intracellular pathogens, induction of cytokines, and enhancement of some membrane molecule expression. Study groups consisted of nine psoriatic and nine normal subjects. Using a commercially available immune-enzyme method, IL-7 concentrations were determined in various samples: biopsy and scale exstracts, peripheral blood mononuclear cells (PBMCs) supernatants, and sera. The results show that IL-7 levels are significantly increased both in biopsy and in scale extracts obtained from lesional skin compared to those obtained from nonlesional and normal skin (P at least