UNIT ANALYSIS OF NOCICEPTIVE MECHANISMS IN THALAMUS OF AWAKE SQUIRREL MONKEY
UNIT ANALYSIS OF NOCICEPTIVE MECHANISMS IN THALAMUS OF AWAKE SQUIRREL MONKEY
复制标题
DOI：
10.1152/jn.1966.29.4.727
复制
发表时间：
1966-01-01
影响因子：
2.5
通讯作者：
CASEY, KL
中科院分区：
文献类型：
--
作者：
CASEY, KL
用数字计算机分析丘脑内侧板内和丘脑后外侧各单位的活动。伤害性刺激被定义为那些总是引起被刺激部分退出的刺激。动物S的觉醒水平是根据行为和生理标准确定的，按唤醒程度的递增顺序被命名为S1、S2或S3。在142个对躯体刺激作出反应的单位中，没有一个是专门对伤害性刺激作出反应的。在S1或S3只对伤害性刺激有反应的神经元，在S2对无害刺激有反应。34个单位对广泛的躯体刺激作出反应，足够稳定，可以比较S2期间传递的伤害性和无害躯体刺激的反应。对于这些单位中的相当大一部分，伤害性刺激产生了更大的放电频率变化。结果表明，痛感与某些神经元活动的独特变化有关，而不是与仅存在于伤害性感受元素的活动有关。
The activity of units recorded from the medial-intralaminar and posterolateral thalamus was analyzed with the aid of a digital computer. Noxious stimuli were defined as those which always produced withdrawal of the stimulated part. The animal''s level of wakefulness, established according to behavioral and physiological criteria, was designated S1, S2 or S3, in order of increasing arousal. Of 142 units responding to somatic stimuli, none responded exclusively to noxious stimuli. Those neurons which responded only to noxious stimuli in S1 or S3, responded to innocuous stimuli in S2. Thirty-four units, responding to widespread somatic stimuli, were sufficiently stable to allow a comparison of the responses to noxious and innocuous somatic stimuli delivered during S2. For a significant proportion of these units, noxious stimuli produced the greater shift in discharge frequency. The results suggest that pain sensation is associated with distinctive changes in the activity of certain neurons, rather than with the presence of activity in exclusively nociceptive elements.