mRNA from human colon tumor and mucosa related to the pol gene of an endogenous A-type retrovirus.
mRNA from human colon tumor and mucosa related to the pol gene of an endogenous A-type retrovirus.
复制标题
来自人类结肠肿瘤和粘膜的 mRNA，与内源 A 型逆转录病毒的 pol 基因相关。
DOI：
10.1016/s0006-291x(86)80286-8
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发表时间：
1986
影响因子：
3.1
通讯作者：
Huang,RC
中科院分区：
文献类型：
--
作者：
Moshier,JA;Luk,GD;Huang,RC
内源性逆转录病毒基因在哺乳动物中的表达可能与包括癌症在内的遗传性疾病有关。最近，A型人内源性逆转录病毒基因组已被克隆使用的逆转录酶（pol）基因的啮齿动物脑池内A-颗粒（IAP）。本研究将人结肠腺癌及其周围粘膜的RNA与小鼠IAPpolandgag基因杂交，以检测人内源性A型逆转录病毒的表达。在两种组织中均检测到与小鼠IAPpolgene同源的丰富的、大小不均一的聚腺苷酸化转录物。未发现与小鼠IAP gag区同源的转录物。
The expression of endogenous retroviral genes in mammals may be etiologically related to genetic diseases including cancer. Recently, A-type human endogenous retroviral genomes have been cloned using the reverse transcriptase (pol) genes of rodent intracisternal A-particles (IAP). In this report, RNA from human colon adenocarcinoma and surrounding mucosa was hybridized to mouse IAPpolandgaggenes to examine the expression of human endogenous A-type retroviruses. Abundant, heterogeneous size, polyadenylated transcripts homologous to the mouse IAPpolgene were detected in both tissues. Transcripts homologous to the mouse IAPgagregion were not found.