Relationship of nonspecific antiarrhythmic and negative inotropic activity with physicochemical parameters of propranolol analogues.
Relationship of nonspecific antiarrhythmic and negative inotropic activity with physicochemical parameters of propranolol analogues.
复制标题
非特异性抗心律失常和负性肌力活性与普萘洛尔类似物的理化参数的关系。
DOI：
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发表时间：
1979
影响因子：
7.3
通讯作者：
J. K. Baker
中科院分区：
文献类型：
--
作者：
D. Rauls;J. K. Baker
In an attempt to separate the nonspecific antiarrhythmic activity of propranolol from its negative inotropic effects, analogues containing hydrophilic and lipophilic substituents on the nitrogen and on the naphthyl ring were prepared and tested in an isolated tissue preparation. Though it had been predicted that analogues containing a very hydrophilic group on the nitrogen would have the highest antiarrhythmic/negative inotropic effect ratio, it was found that both effects increased identically when the lipophilicity of either the nitrogen or ring substituent was increased.
