Detection of varicella-zoster virus DNA in nasopharyngeal secretions of immune household contacts of varicella.
Detection of varicella-zoster virus DNA in nasopharyngeal secretions of immune household contacts of varicella.
复制标题
水痘家庭接触者免疫接触者鼻咽分泌物中水痘带状疱疹病毒DNA的检测。
DOI：
10.1093/infdis/168.5.1253
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Bernstein,DI
中科院分区：
文献类型：
--
作者：
Connelly,BL;Stanberry,LR;Bernstein,DI
对水痘-带状疱疹病毒（VZV）免疫的人在接触水痘后没有发生临床感染的风险。然而，它们在多大程度上可能作为VZV传播给其他人的载体尚不清楚。这方面的信息将是重要的，在建立医院感染控制政策，特别是在有关照顾免疫功能低下的主机。应用聚合酶链反应检测系统检测水痘患儿家庭接触者鼻咽分泌物中VZV DNA的存在。在确诊水痘家庭病例后3天内，在5名免疫成人中的4名和1名易感同胞中检出VZV DNA。需要进一步的调查，以确定这是否代表一个有限的窗口VZV复制在鼻咽的免疫人，在此期间，他们可能作为VZV的载体。
Persons immune to varicella-zostervirus (VZV)are not at risk for developingclinical infection after exposure to varicella. However, the extent to which they might serve as vectors for the transmission of VZV to others is not known. Information in this regard would be important in establishing hospital infection control policies, especially in relation to the care of immunocompromised hosts. A polymerase chain reaction-based detection system was used to detect the presence of VZV DNA in the nasopharyngeal secretions of household contacts of children with varicella. VZV DNA was identified in 4 of 5 immune adults and 1 susceptible sibling when sampled within 3 daysof recognition of a household case of varicella. Further investigations are needed to determine whether this represents a limited window of VZV replication in the nasopharynx of immune persons during which they may serve as vectors of VZV.