Isolating the molecular suspect: HLA transgenic mice in the study of human autoimmune disease.
Isolating the molecular suspect: HLA transgenic mice in the study of human autoimmune disease.
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分离分子嫌疑人：人类自身免疫性疾病研究中的 HLA 转基因小鼠。
DOI：
10.1093/rheumatology/38.8.697
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Sønderstrup,G
中科院分区：
文献类型：
--
作者：
Hall,FC;Cope,AP;Patel,SD;Sønderstrup,G
HLA is only one piece of the puzzle autoimmune disease, there is good evidence that HLA molecules also influence host defence against foreign HLA-associated autoimmune diseases are complex, arising as a result of the interaction of environmental pathogens [3, 4], allergic responses and anti-tumour immunity [5]. influences with a polygenic background of susceptibility. In some cases, HLA appears to exert a large influence A variety of hypotheses have been advanced, based on current understanding of the biology of HLA on the susceptibility to disease and in other diseases it is a relatively small component. molecules, to explain the HLA association with disease [6]. Crystallographic studies have demonstrated that
