Maintaining accuracy at the expense of speed: Stimulus similarity defines odor discrimination time in mice
Maintaining accuracy at the expense of speed: Stimulus similarity defines odor discrimination time in mice
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DOI：
10.1016/s0896-6273(04)00753-6
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发表时间：
2004-12-02
期刊：
影响因子：
16.2
通讯作者：
Schaefer, AT
中科院分区：
文献类型：
--
作者：
Abraham, NM;Spors, H;Schaefer, AT
评估了气味辨别时间及其对刺激相似性的依赖性，以测试小鼠气味表征的时间和空间模型。在一种“做/不做”操作性条件反射范式中，测定了简单单分子气味和二元气味混合物的辨别准确性和时间。小鼠辨别简单气味的准确率超过95%。在嗅球中引起高度重叠的时空活动模式的二元混合物也能被同样很好地辨别。然而，虽然小鼠辨别简单气味用时不到200毫秒，但辨别高度相似的二元混合物则需要多70 - 100毫秒的时间。我们得出结论，小鼠的气味辨别速度快且依赖于刺激。因此，潜在的神经元机制作用于快速的时间尺度，只需要一个短暂的气味特异性时空表征阶段就能实现对不同气味的快速辨别。然而，对高度相似刺激的精细辨别需要活动的时间整合，这表明在准确性和速度之间存在一种权衡。
Odor discrimination times and their dependence on stimulus similarity were evaluated to test temporal and spatial models of odor representation in mice. In a go/ no-go operant conditioning paradigm, discrimination accuracy and time were determined for simple monomolecular odors and binary mixtures of odors. Mice discriminated simple odors with an accuracy exceeding 95%. Binary mixtures evoking highly overlapping spatiotemporal patterns of activity in the olfactory bulb were discriminated equally well. However, while discriminating simple odors in less than 200 ms, mice required 70-100 ms more time to discriminate highly similar binary mixtures. We conclude that odor discrimination in mice is fast and stimulus dependent. Thus, the underlying neuronal mechanisms act on a fast timescale, requiring only a brief epoch of odor-specific spatiotemporal representations to achieve rapid discrimination of dissimilar odors. The fine discrimination of highly similar stimuli, however, requires temporal integration of activity, suggesting a tradeoff between accuracy and speed.