Prediction of the development of tolerance to milk in children with cow's milk hypersensitivity
Prediction of the development of tolerance to milk in children with cow's milk hypersensitivity
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DOI：
10.1016/j.jpeds.2003.10.063
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发表时间：
2004-02-01
影响因子：
5.1
通讯作者：
Koskinen, P
中科院分区：
文献类型：
--
作者：
Vanto, T;Helppilä, S;Koskinen, P
目的探讨皮肤点刺试验(SPT)和血清总或特异性免疫球蛋白E(IgE)在诊断奶牛磨坊超敏反应(CMH)时检测血清中总免疫球蛋白E(IgE)水平能否预测4岁婴儿对CM的耐受性。结果在2、3和4岁时，延迟反应儿童比即时反应儿童更快地形成对CM的耐受性：、92%和96%，分别为31%、53%和63%。在39例持续性CMH中，SPT中风轮大小=5 mm的正确诊断率为71%。牛奶特异性免疫球蛋白E
Objectives To investigate whether the development of tolerance to cow's mills (CM) by aged 4 years can be predicted with a skin prick test (SPT) and measurements of total or specific immunoglobulin E (IgE) in the serum, taken at the time of diagnosis of cow's mills hypersensitivity (CMH).Study design Infants with immediate (n = 95) or delayed (n = 67) challenge reactions to CM were prospectively followed to aged 4 years. CMH status was assessed annually by CM challenges.Results By aged 2, 3, and 4 years, children with delayed reactions developed tolerance to CM faster than those with immediate reactions: 64%, 92%, and 96% versus 31%, 53%, and 63%, respectively. A wheal size of = 5 mm in SPT correctly identified 71% of 39 infants with persistent CMH. Milk-specific IgE