Recent Progress in the Drug Development Targeting SARS-CoV-2 Main Protease as Treatment for COVID-19.
Recent Progress in the Drug Development Targeting SARS-CoV-2 Main Protease as Treatment for COVID-19.
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针对SARS-COV-2主要蛋白酶作为Covid-19的药物开发的最新进展。
DOI：
10.3389/fmolb.2020.616341
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发表时间：
2020
影响因子：
5
通讯作者：
Yang H
中科院分区：
文献类型：
--
作者：
Cui W;Yang K;Yang H
2019年突然爆发的新型冠状病毒（2019- ncov，后来被命名为SARS-CoV-2）迅速演变为前所未有的2019年冠状病毒病（COVID-19）大流行。这是进入新千年以来人类社会第三次出现致命的冠状病毒（CoV），它使全球医疗体系不堪重负，并影响了全球经济。然而，COVID-19的治疗选择仍然非常有限。开发针对病毒生命周期中重要蛋白的药物是克服这一困境的可行途径。主蛋白酶（Mpro）在加工冠状病毒编码的多蛋白中起主导作用，介导复制转录机制的组装，因此被认为是理想的抗病毒靶点。本文综述了近年来抗sars - cov -2抗Mpro药物的发现进展。结合结构研究、虚拟筛选和实验筛选，已经提出了许多治疗候选药物，包括重新利用药物和从头开始设计的化合物。科学界的这种合作努力将加快开发有效治疗COVID-19的步伐。
The sudden outbreak of 2019 novel coronavirus (2019-nCoV, later named SARS-CoV-2) rapidly turned into an unprecedented pandemic of coronavirus disease 2019 (COVID-19). This global healthcare emergency marked the third occurrence of a deadly coronavirus (CoV) into the human society after entering the new millennium, which overwhelmed the worldwide healthcare system and affected the global economy. However, therapeutic options for COVID-19 are still very limited. Developing drugs targeting vital proteins in viral life cycle is a feasible approach to overcome this dilemma. Main protease (Mpro) plays a dominant role in processing CoV-encoded polyproteins which mediate the assembly of replication-transcription machinery and is thus recognized as an ideal antiviral target. Here we summarize the recent progress in the discovery of anti-SARS-CoV-2 agents against Mpro. Combining structural study, virtual screen, and experimental screen, numerous therapeutic candidates including repurposed drugs and ab initio designed compounds have been proposed. Such collaborative effort from the scientific community would accelerate the pace of developing efficacious treatment for COVID-19.
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影响因子：
16.8
作者：
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DOI：
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