SAFB1's Multiple Functions in Biological Control-Lots Still to Be Done!
SAFB1's Multiple Functions in Biological Control-Lots Still to Be Done!
复制标题
DOI：
10.1002/jcb.22420
复制
发表时间：
2010-02-01
影响因子：
4
通讯作者：
Oesterreich, Steffi
中科院分区：
文献类型：
--
作者：
Garee, Jason P.;Oesterreich, Steffi
对支架附着因子B1（SAFB 1）及其在细胞过程中的多种功能和任务的研究，为深入了解其在疾病（如癌症）中的作用提供了依据。SAFB 1是一个大的多结构域蛋白，在转录抑制和RNA剪接中具有良好的功能。它广泛表达，并已被证明在许多细胞过程中是重要的，包括细胞生长，应激反应和凋亡。SAFB 1是一个蛋白质家族的一部分，该家族至少有两个其他家族成员，SAFB 2和SAFB样转录调节因子SLTM。这篇前景文章的目的是总结SAFB 1的已知功能，及其在细胞过程中的作用，但也推测不太好的描述。SAFB 1的新特性，例如在染色质组织中的潜在作用。这次及时的审查显示了SAFB 1的各个方面，这些方面的复杂性远远超过了以前的想象。J.细胞。109：312-319，2010. (C)2009 Wiley-Liss，Inc.
The examination of scaffold attachment factor B1 (SAFB1) and its Multiple functions and tasks in cellular processes provides insight into its role in diseases, such as cancer. SAFB1 is a large multi-domain protein with well-described functions in transcriptional repression, and RNA Splicing. It is ubiquitously expressed, and has been shown to be important in numerous cellular processes including cell growth, stress response, and apoptosis. SAFB1 is part of a protein family with at least two other family members, SAFB2 and the SAFB-like transcriptional modulator SLTM. The goal of this prospect article is to summarize known functions of SAFB1, and its roles in cellular processes, but also to speculate on less well described. novel attributes of SAFB1, Such as a potential role in chromatin organization. This timely review shows aspects of SAFB1, which are proving to have a complexity far greater than was previously thought. J. Cell. Biochem. 109: 312-319, 2010. (C) 2009 Wiley-Liss, Inc.