Safety and immunogenicity of a diphtheria, tetanus, and acellular pertussis-inactivated poliovirus vaccine/Haemophilus influenzae type B combination vaccine administered to Taiwanese infants at 2, 4, and 6 months of age.
Safety and immunogenicity of a diphtheria, tetanus, and acellular pertussis-inactivated poliovirus vaccine/Haemophilus influenzae type B combination vaccine administered to Taiwanese infants at 2, 4, and 6 months of age.
复制标题
白喉、破伤风和无细胞百日咳灭活脊髓灰质炎病毒疫苗/B 型流感嗜血杆菌联合疫苗给 2、4 和 6 个月大的台湾婴儿注射的安全性和免疫原性。
DOI：
--
复制
发表时间：
2003
期刊：
影响因子：
--
通讯作者：
H. Bock
中科院分区：
文献类型：
--
作者：
Tzou;Ying;Luan;C. Chiu;Yhu;Haiwen Tang;H. Bock
背景
迫切需要联合疫苗，以确保符合越来越多的儿童推荐疫苗的要求。我们评估了给 2、4 和 6 个月大的婴儿接种白喉、破伤风和无细胞百日咳灭活脊髓灰质炎病毒疫苗/b 型流感嗜血杆菌 (DTaP-IPV/Hib) 联合疫苗的安全性和抗体反应。
方法
招募了 60 名 6 至 12 周龄的健康婴儿。一组疫苗单次注射接受 DTaP-IPV/Hib，而另一组在不同的注射部位同时接受 DTaP-IPV 和 Hib。通过父母的观察来监测所引起的不良事件，并将其记录在日记卡上。在第一剂疫苗接种前和第三剂疫苗接种后 1 个月收集针对 DTaP 和聚核糖基核糖醇磷酸酯破伤风 (PRP-T) 抗原的血清抗体水平。
结果
与单独注射组相比，联合注射组的局部反应往往较低，并且反应原性没有增加。除联合注射组的抗脊髓灰质炎 2 抗体 (96.4%) 外，两组所有抗原的血清转化率均为 100%。联合注射组的PRP抗体水平（8.45微克/毫升）低于单独注射组（20.61微克/毫升）。然而，两组中达到 PRP 抗体保护水平（≥ 0.15 微克/毫升或≥ 1.0 微克/毫升）的疫苗百分比相似。
结论
使用 2、4 和 6 个月的疫苗接种计划，可以安全有效地对健康婴儿施用 DTaP-IPV/Hib。这种联合疫苗具有成本效益，更容易被父母和医生接受，并最大限度地减少婴儿的痛苦。
BACKGROUND
Combined vaccines are urgently needed to ensure compliance with the increasing number of recommended vaccines for children. We evaluated the safety and antibody response to a diphtheria, tetanus, and acellular pertussis-inactivated poliovirus vaccine/Haemophilus influenzae type b (DTaP-IPV/Hib) combination vaccine administrated to infants at 2, 4, and 6 months of age.
METHODS
Sixty healthy infants between 6 and 12 weeks of age were enrolled. One group of vaccines received the DTaP-IPV/Hib in a single injection, while another group concurrently received DTaP-IPV and Hib at separate injection sites. Solicited adverse events were monitored by parental observation and were recorded on a diary card. Levels of serum antibodies to DTaP and polyribosyl-ribitolphosphate-tetanus (PRP-T) antigens were collected before the first vaccine dose and 1 month after the third vaccine dose.
RESULTS
The combined-injection group tended to have lower local reactions, and there was no increase in reactogenicity when compared with the separate-injection group. Seroconversion rates were 100% in both groups for all antigens, except for the anti-polio 2 antibody in the combined-injection group (96.4%). The combined-injection group had lower antibody levels of PRP (8.45 microg/ml) than did the separate-injection group (20.61 microg/ml). However, the percentage of vaccines achieving protective levels of antibody to PRP (> or = 0.15 microg/ml or > or = 1.0 microg/ml) was similar in both groups.
CONCLUSIONS
DTaP-IPV/Hib may be safely and effectively administered to healthy infants, using a 2-, 4-, and 6-month vaccination schedule. This combined vaccine is cost-effective, more acceptable to parents and physicians, and minimizes distress to infants.
影响因子：
158.5
作者：
Gustafsson, L;Hallander, HO;Storsaeter, J
通讯作者：
Storsaeter, J
由无细胞百日咳疫苗组成的联合疫苗。
DOI：
10.1097/00006454-199704001-00005
发表时间：
1997
期刊：
The Pediatric infectious disease journal
影响因子：
--
作者：
Edwards,KM;Decker,MD
通讯作者：
Decker,MD