TRANSIENT HYPEROXALURIA AFTER INGESTION OF CHOCOLATE AS A HIGH-RISK FACTOR FOR CALCIUM-OXALATE CALCULI
TRANSIENT HYPEROXALURIA AFTER INGESTION OF CHOCOLATE AS A HIGH-RISK FACTOR FOR CALCIUM-OXALATE CALCULI
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DOI：
10.1159/000185238
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发表时间：
1989-01-01
期刊：
影响因子：
2.5
通讯作者：
SCHMIDT, P
中科院分区：
文献类型：
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作者：
BALCKE, P;ZAZGORNIK, J;SCHMIDT, P
在6名男性受试者中，研究了摄入富含草酸的食物——巧克力后尿草酸排泄的日变化。由于巧克力在上消化道被吸收，其摄入导致尿草酸排泄显著但短暂地增加。摄入巧克力后2 - 4小时排泄率达到峰值。在摄入50克巧克力的试验中，峰值为空腹排泄率的235%，在摄入100克巧克力的试验中为289%，达到了原发性高草酸尿症患者的水平。雷尼替丁的使用对草酸吸收没有影响。观察到的短暂性高草酸尿似乎是有结石疾病风险的患者形成草酸钙结石的一个重要因素。
In 6 male subjects the diurnal variation of urinary oxalic acid excretion was studied after ingestion of chocolate, a food stuff rich in oxalic acid. The ingestion of chocolate caused a striking but transient increase in urinary oxalic acid excretion due to its absorption in the upper gastrointestinal tract. The peak excretion rates occurred 2-4 h after the intake of the chocolate. The peak values were 235% of the fasting excretion rate in the trial with 50 g chocolate and 289% in the trial with 100 g chocolate and rached the amounts found in cases with primary hyperpoxaluria. The administration of ranitidine had no influence on oxalic acid absorption. The transient hyperoxaluria observed seems to be an important factor for the formation of calcium oxalate calculi in patients on risk for stone disorders.