Use of statins and risk of glioma: a nationwide case-control study in Denmark
Use of statins and risk of glioma: a nationwide case-control study in Denmark
复制标题
DOI：
10.1038/bjc.2012.536
复制
发表时间：
2013-02-19
影响因子：
8.8
通讯作者：
Friis, S.
中科院分区：
文献类型：
--
作者：
Gaist, D.;Andersen, L.;Friis, S.
背景：实验室研究和单一病例对照研究表明，他汀类药物对胶质瘤的风险具有保护作用。我们希望调查的影响，他汀类药物的使用对神经胶质瘤的风险在人口为基础的setting.Methods：我们进行了一项全国性的病例对照研究，在丹麦的基础上，以人口为基础的医疗登记。我们确定了2000年至2009年期间首次诊断为组织学证实的胶质瘤的所有患者，年龄在20至85岁之间。这些病例在出生年份和性别上与人口对照相匹配。自1995年以来，既往使用他汀类药物被归类为短期使用（
Background: Laboratory studies and a single case-control study have suggested a protective effect of statins on the risk of glioma. We wished to investigate the influence of statin use on the risk of glioma in a population-based setting.Methods: We conducted a nationwide case-control study in Denmark based on population-based medical registries. We identified all patients aged 20 to 85 years with a first diagnosis of histologically verified glioma during 2000-2009. These cases were matched on birth year and sex with population controls. Prior use of statins since 1995 was classified into short-term use (