Independent strong association of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe mucosal involvement.
Independent strong association of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe mucosal involvement.
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DOI：
10.1038/srep04862
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发表时间：
2014-04-30
影响因子：
4.6
通讯作者：
Kinoshita S
中科院分区：
文献类型：
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作者：
Ueta M;Kaniwa N;Sotozono C;Tokunaga K;Saito Y;Sawai H;Miyadera H;Sugiyama E;Maekawa K;Nakamura R;Nagato M;Aihara M;Matsunaga K;Takahashi Y;Furuya H;Muramatsu M;Ikezawa Z;Kinoshita S
Stevens-Johnson综合征（SJS）及其严重变体中毒性表皮坏死松解症（TEN）是皮肤和粘膜的急性炎性大疱性反应。据报道，包括非甾体抗炎药（NSAID）和多成分感冒药在内的感冒药是重要的煽动药物。我们使用两组日本患者样本研究HLA基因型与感冒药相关SJS/TEN（CM-SJS/TEN）之间的关联，包括伴有严重粘膜受累（如严重眼表并发症（SOC））的对乙酰氨基酚相关SJS/TEN（AR-SJS/TEN）。HLA-A*02：06与CM-SJS/TEN伴SOC和AR-SJS/TEN伴SOC密切相关。HLA-B*44：03也被检测为CM-的独立风险等位基因，包括AR-SJS/TEN伴SOC。使用从无SOC的CM-SJS/TEN患者和患有与CM无关的SJS/TEN伴SOC患者获得的数据进行的分析表明，这两个易感等位基因仅参与CM-SJS/TEN伴SOC患者的发展。
Stevens-Johnson syndrome (SJS) and its severe variant, toxic epidermal necrolysis (TEN), are acute inflammatory vesiculobullous reactions of the skin and mucous membranes. Cold medicines including non-steroidal anti-inflammatory drugs (NSAIDs) and multi-ingredient cold medications are reported to be important inciting drugs. We used two sample sets of Japanese patients to investigate the association between HLA genotypes and cold medicine-related SJS/TEN (CM-SJS/TEN), including acetaminophen-related SJS/TEN (AR-SJS/TEN) with severe mucosal involvement such as severe ocular surface complications (SOC). HLA-A*02:06 was strongly associated with CM-SJS/TEN with SOC and AR-SJS/TEN with SOC. HLA-B*44:03 was also detected as an independent risk allele for CM-, including AR-SJS/TEN with SOC. Analyses using data obtained from CM-SJS/TEN patients without SOC and patients with CM-unrelated SJS/TEN with SOC suggested that these two susceptibility alleles are involved in the development of only CM-SJS/TEN with SOC patients.