Quantitative metabolic parameters measured on F-18 FDG PET/CT predict survival after relapse in patients with relapsed epithelial ovarian cancer
Quantitative metabolic parameters measured on F-18 FDG PET/CT predict survival after relapse in patients with relapsed epithelial ovarian cancer
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DOI：
10.1016/j.ygyno.2014.12.032
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发表时间：
2015-03-01
影响因子：
4.7
通讯作者：
Lee, Jaetae
中科院分区：
文献类型：
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作者：
Kim, Choon-Young;Jeong, Shin Young;Lee, Jaetae
目标。本研究旨在评价F-18 FOG PET/CT （FDG PET/CT）在复发性上皮性卵巢癌（EOC）患者首次复发时定量代谢参数的预后价值。回顾性分析56例复发的EOC患者。在FDG PET/CT上测量首次复发时的定量代谢参数，包括最大标准化摄取值（SUVmax）、全身代谢肿瘤体积（WBMTV）和全身病变总糖酵解（WBTLG）。复发后生存期（PRS）计算自疾病复发诊断至死亡或最后一次随访。使用临床和定量代谢参数对PRS进行单因素和多因素分析。32例患者在随访期间（中位：462个月）死于该疾病。在单因素和多因素分析中，无铂间隔、二线治疗类型、WBMTV和WBTLG都是PRS的重要预后因素。与其他亚组相比，低WBMTV和低WBTLG的铂敏感亚组预后更好（log-rank检验，p < 0.001）。行二次细胞减少手术（SCS）后再行二线化疗的患者PRS持续时间明显长于仅行二线化疗的患者（平均PRS = 61 vs 36个月，chi(2) = 8.68, p = 0.032）。我们的研究结果表明，在第一次复发时FDG PET/CT上测量的定量代谢参数对PRS有显著的预测价值。结合定量代谢参数和常规临床参数比单独使用常规临床参数对预后有更好的判别。(C) 2014爱思唯尔公司版权所有。
Objective. This study aimed to evaluate the prognostic value of quantitative metabolic parameters measured on F-18 FOG PET/CT (FDG PET/CT) at the time of the first relapse in patients with relapsed epithelial ovarian cancer (EOC).Methods. Fifty-six relapsed EOC patients were retrospectively included. Quantitative metabolic parameters including maximum standardized uptake value (SUVmax), whole-body metabolic tumor volume (WBMTV), and whole-body total lesion glycolysis (WBTLG) were measured on FDG PET/CT at the time of the first relapse. Post-relapse survival (PRS) was calculated from the date of diagnosis of relapsed disease to the date of death or last follow-up. Univariate and multivariate analyses for PRS were performed using clinical and quantitative metabolic parameters.Results. Thirty-two patients died from the disease during the follow-up period (median: 462 months). On univariate and multivariate analyses, the platinum-free interval, type of second-line treatment, WBMTV, and WBTLG were all significant prognostic factors for PRS. The subgroup of patients who were platinum-sensitive with low WBMTV and low WBTLG showed better prognosis, when compared with other subgroups (log-rank test, p < 0.001). Patients treated with secondary cytoreductive surgery (SCS) followed by second-line chemotherapy showed significantly longer duration of PRS than patients treated with second-line chemotherapy only (mean PRS = 61 vs. 36 months, chi(2) = 8.68, p = 0.032).Conclusion. Our results suggest that quantitative metabolic parameters measured on FDG PET/CT at the time of the first relapse have significant predictive values for PRS. Incorporating quantitative metabolic parameters and conventional clinical parameters has a superior prognostic discrimination compared with conventional clinical parameters alone. (C) 2014 Elsevier Inc. All rights reserved.