The Latest in Animal Models of Pulmonary Hypertension and Right Ventricular Failure.
The Latest in Animal Models of Pulmonary Hypertension and Right Ventricular Failure.
复制标题
最新的肺动脉高压和右心室衰竭动物模型。
DOI：
10.1161/circresaha.121.319971
复制
发表时间：
2022-04-29
影响因子：
20.1
通讯作者：
Bonnet S
中科院分区：
文献类型：
--
作者：
Boucherat O;Agrawal V;Lawrie A;Bonnet S
肺动脉高压（PH）描述了平均肺动脉压大于20mmhg的异质人群。PH很少表现为原发性疾病，但更常见的是与合并症相关的复杂表型的一部分。不管是什么原因，酸碱度都会降低预期寿命，影响生活质量。目前的临床分类将PH分为5个诊断组之一，以分配治疗。目前还没有任何形式的ph的药物治疗方法。动物模型对于帮助破译疾病的分子机制，分配基因型-表型关系以帮助确定新的治疗靶点，以及临床翻译以评估作用机制和新疗法的假定疗效至关重要。然而，所有动物疾病模型固有的局限性限制了任何单一模型完全概括复杂人类疾病的能力。在PH社区中，我们经常批评动物模型，因为新药临床转化的成功率很低。在这篇综述中，我们描述了现有动物模型的特点，优点和缺点，以深入了解分子和病理机制，并测试新的治疗方法，重点是从1到3组的成年形式的PH。为了更好地反映临床情况并提高其转化价值，我们还讨论了结合几种hit方法的动物模型的改进领域。
Pulmonary hypertension (PH) describes heterogeneous population of patients with a mean pulmonary arterial pressure greater than 20 mmHg. Rarely, PH presents as a primary disorder but is more commonly part of a complex phenotype associated with co-morbidities. Regardless of cause, PH reduces life expectancy and impacts quality of life. The current clinical classification divides PH into one of 5 diagnostic groups to assign treatment. There are currently no pharmacological cures for any form of PH. Animal models are essential to help decipher the molecular mechanisms underlying the disease, to assign genotype-phenotype relationships to help identify new therapeutic targets, and for clinical translation to assess the mechanism of action and putative efficacy of new therapies. However, limitations inherent of all animal models of disease limit the ability of any single model to fully recapitulate complex human disease. Within the PH community, we are often critical of animal models due to the perceived low success upon clinical translation of new drugs. In this review, we describe the characteristics, advantages and disadvantages of existing animal models developed to gain insight into the molecular and pathological mechanisms and test new therapeutics, focusing on adult forms of PH from groups 1 to 3. We also discuss areas of improvement for animal models with approaches combining several hits in order to better reflect the clinical situation and elevate their translational value.
影响因子：
3.7
作者：
Zeng GQ;Liu R;Liao HX;Zhang XF;Qian YX;Liu BH;Wu QH;Zhao J;Gu WW;Li HT
通讯作者：
Li HT