Altered functional connectivity in early Alzheimer's disease: A resting-state fMRI study
Altered functional connectivity in early Alzheimer's disease: A resting-state fMRI study
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DOI：
10.1002/hbm.20324
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发表时间：
2007-10-01
影响因子：
4.8
通讯作者：
Jiang, Tianzi
中科院分区：
文献类型：
--
作者：
Wang, Kun;Liang, Meng;Jiang, Tianzi
先前的研究已经提出，阿尔茨海默病（AD）患者可能扰乱了不同大脑区域之间的功能连接。此外，最近的静息态功能磁共振成像（fMRI）研究也表明，在AD患者的几个脑区的血氧水平依赖性信号的低频（< 0.08 Hz）波动（LFF）是异常的。然而，很少有研究调查AD患者LFF连接紊乱。本研究利用静息态fMRI研究早期AD患者全脑异常的功能连接，并分析这些异常的全球分布。为此，作者将整个大脑分为116个区域，并通过比较每对区域的相关系数来识别异常连接。与健康对照组相比，AD患者前额叶和顶叶之间的正相关降低，但前额叶、顶叶和枕叶之间的正相关增加。AD患者的两个内在反相关网络之间的负相关性也降低（接近于零），这是以前在静息脑中发现的。通过使用静息状态FVRI，我们的研究结果支持了先前的研究，即AD患者存在前后连接断开现象，并增加了叶内功能连接。此外，研究结果还表明，AD可能会干扰两个本征反相关网络中的相关/反相关效应。
Previous studies have led to the proposal that patients with Alzheimer's disease (AD) may have disturbed functional connectivity between different brain regions. Furthermore, recent resting-state functional magnetic resonance imaging (fMRI) studies have also shown that low-frequency (< 0.08 Hz) fluctuations (LFF) of the blood oxygenation level-dependent signals were abnormal in several brain areas of AD patients. However, few studies have investigated disturbed LFF connectivity in AD patients. By using resting-state fMRI, this study sought to investigate the abnormal functional connectivities throughout the entire brain of early AD patients, and analyze the global distribution of these abnormalities. For this purpose, the authors divided the whole brain into 116 regions and identified abnormal connectivities by comparing the correlation coefficients of each pair. Compared with healthy controls, AD patients had decreased positive correlations between the prefrontal and parietal lobes, but increased positive correlations within the prefrontal lobe, parietal lobe, and occipital lobe. The AD patients also had decreased negative correlations (closer to zero) between two intrinsically anti-correlated networks that had previously been found in the resting brain. By using resting-state FVRI, our results supported previous studies that have reported an anterior-posterior disconnection phenomenon and increased within-lobe functional connectivity in AD patients. In addition, the results also suggest that AD may disturb the correlation/anti-correlation effect in the two intrinsically anti-correlated networks.