Tubulo-interstitial nephritis associated with polyomavirus (BK type) infection.
Tubulo-interstitial nephritis associated with polyomavirus (BK type) infection.
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与多瘤病毒（BK 型）感染相关的肾小管间质性肾炎。
DOI：
10.1056/nejm198305193082004
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Walker,DL
中科院分区：
文献类型：
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作者：
Rosen,S;Harmon,W;Krensky,AM;Edelson,PJ;Padgett,BL;Grinnell,BW;Rubino,MJ;Walker,DL
我们研究了一名患有高免疫球蛋白M免疫缺陷的六岁男孩的肾脏病毒损伤，他表现为不可逆转的急性肾功能衰竭，最终在五个月的透析后死亡。在他提出报告时的肾活检显示，主要是肾小管间质突起，有大量的病毒包涵体，被鉴定为多瘤病毒。尿液培养显示出大量的BK型多瘤病毒。肾脏疾病为终末期，经形态技术和培养证实BK病毒持续存在。DNA杂交分析显示，淋巴结、脾和肺组织中病毒浓度较低。明显的病毒尿、BK病毒的高浓度以及病毒抗原在肾脏的广泛分布都表明BK病毒感染是肾实质严重损伤的基础。《英国医学杂志》1983；308：1192-6。
We studied viral injury to the kidney in a six-year-old boy with hyperimmunoglobulin M immunodeficiency who presented with irreversible acute renal failure and eventually died after five months of dialysis. Renal biopsy at the time of his presentation revealed a predominantly tubulo-interstitial process with numerous viral inclusions that were identified as polyomavirus. Urine cultures showed a massive viruria with BK-type polyomavirus. The kidney disease was end stage, with persistence of BK virus identified by morphologic techniques and by culture. DNA hybridization analysis showed virus in low concentration in the lymph nodes, spleen, and lungs. The marked viruria, the high concentration of BK virus, and the extensive distribution of viral antigen throughout the kidney all suggest that infection with BK virus was the basis of the severe renal parenchymal injury. (N Engl J Med 1983; 308:1192–6.)