Measuring tissue heat penetration by scattered light measurements
Measuring tissue heat penetration by scattered light measurements
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DOI：
10.1002/lsm.20654
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发表时间：
2008-09-01
影响因子：
2.4
通讯作者：
Gannot, I.
中科院分区：
文献类型：
--
作者：
Ben-David, M.;Cantor, R.;Gannot, I.
背景和目的：在激光热疗、激光脱毛等临床治疗过程中，对组织形态变化的监测对于预防对健康组织的损害具有重要意义。提出了一种实时评价活体组织形态变化的光学系统和方法。材料和方法：以离体鸡胸肌为组织标本。这些样品被二氧化碳激光照射，以产生热结构变化。用积分球方法测量了组织样品的光学性质。我们测量了组织的热渗透率和组织的散射光，并将结果与蒙特卡罗模拟进行了比较。结果：热相互作用导致组织结构的变化。因此改变(增加)组织的散射特性。我们将结构变化与散射光图案联系起来，并提出了一种控制热相互作用的方法。结论：利用散射光图案的变化设计一种实时的体内激光组织热相互作用控制系统是可能的。
Background and Objectives: The monitoring of tissue morphological changes during clinical procedure such as laser thermotherapy, laser hair removal and others is important in order to prevent damage to healthy tissue. An optical system and method for the assessment of real time in vivo tissue morphological changes is proposed.Materials and Methods: We used ex vivo chicken breast as tissue samples. The samples were irradiated by CO2 laser to create thermal structural changes. The optical properties of the tissue samples were measured using an integrating sphere method. We measured the tissue heat penetration and the scattered light from the tissue and compared the results to Monte-Carlo simulation.Results: Thermal interaction causes structural changes in the tissue. Therefore changing (increasing) the scattering properties of the tissue. We relate the structural changes to the scattered light pattern and proposed a method for controlling the thermal interaction.Conclusion: It is possible to design a real time in vivo controlling system for laser tissue thermal interaction that utilizes the changes in the scattered light pattern.