Transient outward current, Ito1, is altered in cardiac memory
Transient outward current, Ito1, is altered in cardiac memory
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DOI：
10.1161/01.cir.99.14.1898
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发表时间：
1999-04-13
期刊：
影响因子：
37.8
通讯作者：
Rosen, MR
中科院分区：
文献类型：
--
作者：
Yu, HG;McKinnon, D;Rosen, MR
背景：心脏记忆是指在窦性心律恢复后，由心室起搏或心律失常引起的t波形态改变。方法与结果：通过心室起搏120次/分钟，连续3周诱导有意识犬的长期心脏记忆。每天记录心电图1小时，在此期间停止起搏。在研究末期，取下心脏，观察左心室心外膜肌细胞的电生理。对照组(C)与LTM心电图无显著差异，但t波振幅从0.12+/-0.18 mV降至-0.34+/-0.21 mV (+/-SEM， P
Background-Cardiac memory refers to an altered T-wave morphology induced by ventricular pacing or arrhythmias that persist for variable intervals after resumption of sinus rhythm.Methods and Results-We induced long-term cardiac memory (LTM) in conscious dogs by pacing the ventricles at 120 bpm for 3 weeks. ECGs were recorded daily for I hour, during which time pacing was discontinued At terminal study, the heart was removed and the electrophysiology of left ventricular epicardial myocytes was investigated. Control (C) and LTM ECG did not differ, except for T-wave amplitude, which decreased from 0.12+/-0.18 to -0.34+/-0.21 mV (+/-SEM, P