Prospective memory impairment in individuals with Parkinson's disease
Prospective memory impairment in individuals with Parkinson's disease
复制标题
DOI：
10.1037/0894-4105.22.3.283
复制
发表时间：
2008-05-01
期刊：
影响因子：
2.4
通讯作者：
Carlesimo, Giovanni Augusto
中科院分区：
文献类型：
--
作者：
Costa, Alberto;Peppe, Antonella;Carlesimo, Giovanni Augusto
这项研究调查了帕金森病 (PD) 患者的前瞻性记忆及其与执行和记忆功能的关系。 23 名 PD 患者和 25 名健康对照参与者参与了这项研究。在前瞻性记忆任务中，参与者被要求在 20 分钟后（基于时间的条件）或计时器响起后（基于事件的条件）执行 3 个动作。计算正确回忆执行动作的意图（预期部分）和正确执行动作（回顾部分）的分数。患有帕金森病的参与者还接受了广泛的神经心理学测试。在基于时间的任务的预期部分中，PD 参与者的准确度低于对照参与者，但在基于事件的任务中则不然。患有帕金森病的人在这两项任务的回顾部分也受到损害。在 PD 组中，基于时间的任务的预期记忆部分的表现水平与执行记忆和工作记忆测量的得分之间存在显着相关的总体趋势。这些结果证明帕金森病患者的前瞻记忆受损可能与额叶系统认知功能失调有关。
This study investigated prospective memory and its relationship to executive and memory functions in persons with Parkinson's disease (PD). Twenty-three individuals with PD and 25 healthy comparison participants participated in the study. In the prospective memory tasks, participants were asked to execute 3 actions after 20 min (time-based condition) or after a timer ring (event-based condition). A score was computed for the correct recall of the intention to perform the actions (prospective component) and for the correct execution of the actions (retrospective component). Participants with PD also received an extensive neuropsychological test battery. PD participants were less accurate than comparison participants in the prospective component of the time-based but not the event-based task. Individuals with PD were also impaired on the retrospective component of both tasks. In the PD group, a general trend toward significant correlations was found between performance level on the prospective memory component of the time-based task and scores on executive and working memory measures. These results document that prospective memory is impaired in PD possibly in relation to a dysregulation of cognitive functions associated with frontal systems.