Expanding the Boundaries: Developing a Streamlined Tool for Eco-Footprinting of Pharmaceuticals
Expanding the Boundaries: Developing a Streamlined Tool for Eco-Footprinting of Pharmaceuticals
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DOI：
10.1021/op3003079
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发表时间：
2013-02-01
影响因子：
3.4
通讯作者：
Bhathela, Neil
中科院分区：
文献类型：
--
作者：
Jimenez-Gonzalez, Concepcion;Ollech, Caleb;Bhathela, Neil
美国化学学会绿色化学研究所制药圆桌会议利用过程质量强度（PMI）作为关键的高级别指标，以评估和基准的进展，以实现更可持续的制造。长期目标是逐步采用基于生命周期评估方法的衡量标准。本文介绍了一个精简的PMI和LCA工具的发展，旨在作为标准的早期评估的活性药物成分（API）和精细化学品的合成路线，特别是在路线开发阶段，生命周期库存数据往往是不容易获得。
The American Chemical Society Green Chemistry Institute Pharmaceutical Roundtable has utilized process mass intensity (PMI) as the key high-level metric to evaluate and benchmark progress towards more sustainable manufacturing. The long-term aim is to move towards metrics based on life cycle assessment (LCA) methodologies. This paper describes the development of a streamlined PMI and LCA tool intended to be used as the standard early assessment of synthetic routes for active pharmaceutical ingredients (API) and fine chemicals, especially during the route development stages when life cycle inventory data are often not readily available.