Hide and seek: for HIV-infected CD4+ T cells, playing well comes with maturity.
Hide and seek: for HIV-infected CD4+ T cells, playing well comes with maturity.
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捉迷藏：对于感染 HIV 的 CD4 T 细胞来说，玩得好意味着成熟。
DOI：
10.1172/jci158872
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Jones,RBrad
中科院分区：
文献类型：
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作者：
Leyre,Louise;Jones,RBrad
抗逆转录病毒疗法可抑制 HIV 复制，但会导致受感染的 CD4+T 细胞群中整合有原病毒。虽然大多数这些原病毒都含有缺陷，例如缺失，但一些完整的原病毒仍然存在，并且可以重新启动病毒复制。在本期 JCI 中，Duette、Hiener 及其同事对多年来通过体外功能测定收集的临床样本进行了力作前病毒景观分析。研究人员表明，效应记忆 CD4+T 细胞为来自 CD8+T 细胞的完整原病毒提供了部分避难所，这与相对于不太成熟的 CD4+T 细胞群而言，Nef 介导的 MHC-I 下调效果更好。这一发现表明差异性免疫逃避是一种细胞内在特性，影响前病毒的持久性，并强调 Nef 作为治疗靶点。
Antiretroviral therapy suppresses HIV replication but leaves a population of infected CD4+T cells with integrated proviruses. While most of these proviruses contain defects, such as deletions, some intact proviruses persist and can reinitiate viral replication. In this issue of theJCI, Duette, Hiener, and colleagues performed a tour de force proviral landscape analysis on clinical samples collected over many years with in vitro functional assays. The researchers showed that effector memory CD4+T cells provide partial sanctuary to intact proviruses from CD8+T cells and this was associated with superior Nef-mediated MHC-I downregulation relative to less mature CD4+T cell populations. This finding implicates differential immunoevasion as a cell-intrinsic property, influencing proviral persistence, and highlights Nef as a therapeutic target.