Apigenin alleviates neomycin-induced oxidative damage via the Nrf2 signaling pathway in cochlear hair cells
Apigenin alleviates neomycin-induced oxidative damage via the Nrf2 signaling pathway in cochlear hair cells
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芹菜素通过 Nrf2 信号通路减轻耳蜗毛细胞中新霉素诱导的氧化损伤
DOI：
10.1007/s11684-021-0864-3
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发表时间：
2021-12
影响因子：
8.1
通讯作者：
Yan Chen
中科院分区：
文献类型：
--
作者：
Gaogan Jia;Huanyu Mao;Yanping Zhang;Yusu Ni;Yan Chen
Oxidative stress plays an important role in the pathogenesis of aminoglycoside-induced hearing loss and represents a promising target for treatment. We tested the potential effect of apigenin, a natural flavonoid with anticancer, anti-inflammatory, and antioxidant activities, on neomycin-induced ototoxicity in cochlear hair cellsin vitro. Results showed that apigenin significantly ameliorated the loss of hair cells and the accumulation of reactive oxygen species upon neomycin injury. Further evidence suggested that the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway was activated by apigenin treatment. Disruption of the Nrf2 axis abolished the effects of apigenin on the alleviation of oxidative stress and subsequent apoptosis of hair cells. This study provided evidence of the protective effect of apigenin on cochlear hair cells and its underlying mechanism.
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Wnt 激活可防止新霉素诱导的小鼠耳蜗毛细胞损伤
影响因子：
9
作者：
Liu L;Chen Y;Qi J;Zhang Y;He Y;Ni W;Li W;Zhang S;Sun S;Taketo MM;Wang L;Chai R;Li H
通讯作者：
Li H
影响因子：
5.3
作者：
Ruhl, Douglas;Du, Ting-Ting;Shin, Jung-Bum
通讯作者：
Shin, Jung-Bum
DOI：
10.1056/nejmra1616601
发表时间：
2017-12-21
期刊：
The New England journal of medicine
影响因子：
--
作者：
Cunningham LL;Tucci DL
通讯作者：
Tucci DL
影响因子：
--
作者：
Xu X;Li M;Chen W;Yu H;Yang Y;Hang L
通讯作者：
Hang L
DOI：
10.1016/j.biopha.2018.06.108
发表时间：
2018-09
期刊：
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
影响因子：
--
作者：
Min Yang;Zhenhuan Jiang;Chenguang Li;Yanjuan Zhu;Zhu Li;Yunzhao Tang;C. Ni
通讯作者：
Min Yang;Zhenhuan Jiang;Chenguang Li;Yanjuan Zhu;Zhu Li;Yunzhao Tang;C. Ni