Insights from genomic microarrays into structural chromosome rearrangements
Insights from genomic microarrays into structural chromosome rearrangements
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DOI：
10.1002/ajmg.a.30378
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发表时间：
2005-01-01
影响因子：
2
通讯作者：
Rosenberg, C
中科院分区：
文献类型：
--
作者：
Knijnenburg, J;Szuhai, K;Rosenberg, C
基于阵列的比较基因组杂交可以对基因组中的拷贝数异常进行高分辨率筛查，并成为检测肿瘤和产后细胞遗传学中的缺失和重复的日益重要的工具。在这里，我们说明基因组阵列还可以提供有关染色体重排的结构基础的新线索，包括环染色体的不稳定性和形成机制。我们还表明，阵列结果可能会影响受影响个体亲属的复发风险。我们的数据表明，染色体重排经常涉及比当前细胞遗传学模型假设的更多断裂。 (C) 2004 Wiley-Liss, Inc.
Array-based comparative genomic hybridization allows high-resolution screening of copy number abnormalities in the genome, and becomes an increasingly important tool to detect deletions and duplications in tumor and post-natal cytogenetics. Here we illustrate that genomic arrays can also provide novel clues regarding the structural basis of chromosome rearrangement, including instability and mechanisms of formation of ring chromosomes. We also showed that array results might impact the recurrence risks for relatives of affected individuals. Our data indicate that chromosome rearrangements frequently involve more breaks than current cytogenetic models assume. (C) 2004 Wiley-Liss, Inc.