A biomimetic lubricating nanosystem with responsive drug release for osteoarthritis synergistic therapy
A biomimetic lubricating nanosystem with responsive drug release for osteoarthritis synergistic therapy
复制标题
具有响应性药物释放的仿生润滑纳米系统用于骨关节炎协同治疗
DOI：
10.1002/adhm.202203245
复制
发表时间：
2023-01
影响因子：
10
通讯作者：
Zhe Liu
中科院分区：
文献类型：
--
作者：
Cheng Li;Peiwei Gong;Mianran Chao;Juan Li;Liyan Yang;Yan Huang;D;an Wang;Jianxi Liu;Zhe Liu
骨关节炎(OA)与关节软骨的润滑失效和关节囊的严重炎症反应有关。结合关节润滑和抗炎的协同疗法是治疗骨性关节炎的一种新方法。本研究以天然关节滑液的超低摩擦力和贻贝的黏附化学为生物灵感，开发了一种具有增强润滑和刺激反应药物释放双重功能的仿生纳米系统。多巴胺介导的策略实现了透明质酸在氟化石墨烯上的一步仿生接枝。聚合物改性薄膜具有高效的近红外吸收性能，在不同的工作条件下表现出稳定的长时间润滑，其中摩擦系数比H2O降低了75%。双氯芬酸钠的载药量高达29.2%，载药量可控，近红外光可调节药物的响应和持续释放。细胞实验表明，润滑的纳米载体被内吞作用摄取，抗炎实验证实纳米系统通过上调软骨合成代谢基因、下调分解代谢酶和疼痛相关基因来抑制骨关节炎的恶化。我们的工作提出了一种很有前途的仿生方法，将聚合物修饰的氟化石墨烯整合为一种新型的双功能纳米系统，用于有效协同治疗骨性关节炎。这篇文章受版权保护。版权所有。
Osteoarthritis (OA) is associated with lubrication failure of articular cartilage and severe inflammatory response of joint capsule. Synergistic therapy combining joint lubrication and anti-inflammation emerges as a novel treatment of OA. In this study, bioinspired by ultra-low friction of natural articular synovial fluid and mussel adhesion chemistry, a biomimetic nanosystem with dual functions of enhanced lubrication and stimuli-responsive drug release was developed. A dopamine mediated strategy realized one step biomimetic grafting of hyaluronic acid on fluorinated graphene. The polymer modified sheets exhibited highly efficient near-infrared absorption, and showed steady lubrication with a long-time under various working conditions, in which the coefficient of friction was reduced by 75% compared to H2 O. Diclofenac sodium with a high loading capacity of 29.2% was controllably loaded, and responsive and sustained drug release was adjusted by near-infrared light. Cell experiments revealed that the lubricating nanocarrier was taken up by endocytosis, and anti-inflammation results confirmed that the nanosystem inhibited osteoarthritis deterioration by up-regulating cartilage anabolic gene and down-regulating catabolic proteases and pain-related gene. Our work proposes a promising biomimetic approach to integrate polymer modified fluorinated graphene as a novel dual-functional nanosystem for effective synergistic therapy of OA. This article is protected by copyright. All rights reserved.