ANECORTAVE ACETATE FOR THE TREATMENT OF IDIOPATHIC PERIFOVEAL TELANGIECTASIA: A Pilot Study
ANECORTAVE ACETATE FOR THE TREATMENT OF IDIOPATHIC PERIFOVEAL TELANGIECTASIA: A Pilot Study
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醋酸阿奈克他治疗特发性中心凹周围毛细血管扩张症：一项初步研究
DOI：
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发表时间：
2006
期刊：
影响因子：
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通讯作者：
L. Yannuzzi
中科院分区：
文献类型：
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作者：
C. Eandi;Michael D. Ober;K. Freund;C. Klais;J. Slakter;J. Sorenson;L. Yannuzzi
目的：在一项开放标签前瞻性先导研究中，研究一种新型血管抑制剂——醋酸anecortave acetate治疗特发性凹周毛细血管扩张症（IPT）相关的渗漏和/或新生血管的应用。方法：对6例7眼患者，采用经特殊设计的弧形套管在黄斑旁注入醋酸anecortave。在基线和每隔3个月进行一次全面的临床检查和荧光素血管造影。这项初步研究的主要疗效终点是从基线开始的平均视力变化（早期治疗糖尿病视网膜病变研究）。结果：2例非增殖性病变患者24个月后双眼视力保持不变。4例患者的5只眼表现为视网膜下新生血管，即IPT的增殖期，最后随访时病变大小稳定或改善，渗漏溶解，视力稳定。结论：醋酸anecortave可能抑制IPT患者视网膜和视网膜下通透性以及新生血管增殖。未来应该设计一个更大的研究来评估IPT的有效性和治疗。
Purpose: To investigate the use of anecortave acetate, a new angiostatic cortisene, for the treatment of the leakage and/or neovascularization associated with idiopathic perifoveal telangiectasia (IPT) in an open label prospective pilot study. Methods: Seven eyes of six patients were treated with posterior juxtascleral administration of anecortave acetate delivered adjacent to the macula using a specially designed curved cannula. A full clinical examination and fluorescein angiography were performed at baseline and at 3-month intervals. The primary efficacy outcome for this pilot study was the mean change in visual acuity (Early Treatment Diabetic Retinopathy Study) from baseline. Results: The visual acuity remained unchanged in two eyes of two patients with nonproliferative disease after 24 months. The five eyes of four patients presenting with subretinal neovascularization, the proliferative stage of IPT, showed stabilization or improvement of lesion size, resolution of leakage, and stabilization of vision at last follow-up. Conclusion: The results of this study suggest that anecortave acetate may inhibit retinal and subretinal permeability as well as neovascular proliferation in patients with IPT. A larger study accordingly should be designed in the future to evaluate the effectiveness and treatment of IPT with this drug.
与特发性中央凹旁毛细血管扩张相关的新生血管膜。
DOI：
10.1001/archopht.120.3.320
发表时间：
2002
期刊：
Archives of ophthalmology (Chicago, Ill. : 1960)
影响因子：
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作者：
Engelbrecht,NicholasE;AabergJr,ThomasM;Sung,Jennie;Lewis,MaryLou
通讯作者：
Lewis,MaryLou