The Application of a Reduced Dye Used in Orthopedics as a Novel Treatment against Coronavirus (COVID-19): A Suggested Therapeutic Protocol
The Application of a Reduced Dye Used in Orthopedics as a Novel Treatment against Coronavirus (COVID-19): A Suggested Therapeutic Protocol
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DOI：
10.22038/abjs.2020.47745.2349
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发表时间：
2020-04-01
影响因子：
1.3
通讯作者：
Yarahmadi, Amir
中科院分区：
文献类型：
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作者：
Alamdari, Daryoush Hamidi;Moghaddam, Ahmad Bagheri;Yarahmadi, Amir
由COVID-19引起的严重急性呼吸系统综合征现在是一个全球性的灾难性事件。目前还没有针对这种疾病的批准药物或疫苗。亚甲蓝（MB，氧化形式，蓝色）已被用于临床医学的许多不同领域，从疟疾到整形外科。根据科学证据，无色亚甲基蓝（MB的还原形式，无色）可用于治疗COVID-19。在重症患者中，存在细胞因子风暴（炎症过度）和高氧化应激（OS）。炎症与OS相互关联，相互加重。在人体内，MB首先通过从其他分子吸收电子（如自由基）来诱导OS，如果身体可以抵消这种OS，那么还原的MB通过其他机制降低OS。减少MB可以防止炎症，病毒RNA的繁殖，并通过减少高铁血红蛋白改善缺氧。因此，为了避免OS增加，我们建议通过以下方案使用无色亚甲蓝：IV混合物含有50 mg MB（1 mg/kg，50 kg体重），1000-2000 mg维生素C，500-1000 mg N-乙酰半胱氨酸（或谷胱甘肽或半胱氨酸或α-硫辛酸）和10-20 gr尿素（可选），溶于100 ml 5%葡萄糖中。注射前，鸡尾酒应在黑暗处放置1-2小时，使其褪色或无色。
The severe acute respiratory syndrome caused by COVID-19 is now a global catastrophic event. Currently there is no approved drug or vaccine for the disease. Methylene blue (MB, oxidized form, blue color) has been used in many different areas of clinical medicine, ranging from malaria to orthopedics. Leucomethylene Blue (reduced form of MB, colorless) may be applied for the treatment of COVID-19 according to the scientific evidences. In severe patients, there is a cytokine storm ( hyperinflammation) and high oxidative stress (OS). Inflammation and OS has a mutual correlation and exacerbate each other. In human body, MB first induces OS through absorbing electron (like a free radical) from other molecules, if the body could counteract to this OS, then reduced MB decreases OS through other mechanisms. Reduced MB could prevent inflammation, propagation of the virus RNA, and also improves hypoxia through reducing methemoglobin. Therefore, to avoid the increment of OS, we suggest using Leucomethylene Blue through the following protocol: The IV cocktail contains 50 mg MB (1mg/kg, 50-kg weight), 1000-2000 mg vitamin C, 500-1000 mg N-Acetylcysteine (or glutathione or cysteine or alpha-lipoic acid) and 10-20 gr urea (optional) in 100 ml dextrose 5%. Before the injection, the cocktail should be kept in a dark place for 1-2 hour to become fade or colorless.