Tuberous Sclerosis Complex and Epilepsy: Prognostic Significance of Electroencephalography and Magnetic Resonance Imaging
Tuberous Sclerosis Complex and Epilepsy: Prognostic Significance of Electroencephalography and Magnetic Resonance Imaging
复制标题
结节性硬化症和癫痫：脑电图和磁共振成像的预后意义
DOI：
10.1177/088307380001500203
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发表时间：
2000
影响因子：
1.9
通讯作者：
W. Grover
中科院分区：
文献类型：
--
作者：
A. Husain;C. Foley;A. Legido;D. A. Chandler;D. Miles;W. Grover
脑硬化症是一种影响许多器官的疾病，包括中枢神经系统。神经系统以错构瘤的形式受累常常导致癫痫发作。在这项研究中，我们想确定结节性硬化症癫痫的结局，并确定发作间期脑电图（EEG）和磁共振成像（MRI）所见的错构瘤负荷是否可预测癫痫控制程度。研究人群包括30例患者。对于每例患者，获得两组EEG和MRI数据，间隔至少12个月，以及数据收集时癫痫发作频率的信息。敏感性，特异性，阳性和阴性预测值的各种脑电图和MRI结果进行了测定。20例患者癫痫控制改善，10例患者恶化。在癫痫控制方面，异常睡眠脑电图的特异性和正常睡眠脑电图的阳性预测值均为100%。MRI和EEG背景对预测癫痫控制既不敏感也不特异。大多数患有结节性硬化症的儿童可以获得良好的癫痫控制。睡眠脑电图有助于预测最终的癫痫控制。（《儿童神经病学杂志》2000;15：81-83）。
Tuberous sclerosis complex is a disease that affects many organs, including the central nervous system. Nervous system involvement in the form of hamartomas often results in seizures. In this study we wanted to determine the outcome of epilepsy in tuberous sclerosis complex and determine whether interictal electroencephalograms (EEGs) and hamartoma burden as seen with magnetic resonance imaging (MRI) are predictive of degree of seizure control. The study population consisted of 30 patients. For each patient two sets of EEG and MRI data, separated by at least 12 months, and information on seizure frequency at time of data collection were obtained. Sensitivity, specificity, and positive and negative predictive values of various EEG and MRI findings were determined. Seizure control improved in 20 and worsened in 10 patients. In relation to seizure control, the specificity of an abnormal sleep EEG and the positive predictive value of normal sleep EEG were 100%. MRI and EEG background were neither sensitive nor specific for predicting seizure control. A majority of children with tuberous sclerosis complex can achieve good seizure control. The sleep EEG is helpful in predicting eventual seizure control. (J Child Neurol 2000;15:81-83).