Early weaning impairs a social contagion of pain-related stretching behavior in mice.
Early weaning impairs a social contagion of pain-related stretching behavior in mice.
复制标题
早期断奶会削弱小鼠与疼痛相关的伸展行为的社会传染性。
DOI：
10.1002/dev.21443
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发表时间：
2016
期刊：
影响因子：
2.2
通讯作者：
Kazutaka Mogi.
中科院分区：
文献类型：
--
作者：
Takefumi Kikusui;Yukino Ishio;Miho Nagasawa;Jeffrey Mogil;Kazutaka Mogi.
小鼠的疼痛敏感性可以通过暴露于熟悉的个体来调节。这种现象被认为是一种情绪传染的形式，被认为是哺乳动物移情的进化前兆。特别是，生命早期的母婴互动可以大大改变同理心的发展。在这里，我们证明了同时给予有害刺激（乙酸）的成对小鼠比其中一对小鼠接受有害刺激时表现出更多的疼痛相关行为。然而，这些差异消失时，小鼠从母鼠分离1周前典型的断奶年龄。即使是单独的老鼠，当用醋酸处理时，早期断奶也会降低它们的疼痛反应。这些结果表明，通过早期断奶破坏母婴联系损害疼痛传染和调节对疼痛的敏感性。
Pain sensitivity in mice can be modulated through exposure to familiar individuals. This phenomenon is considered a form of emotional contagion, thought to be an evolutionary precursor of empathy in mammals. In particular, mother–infant interactions early in life can considerably alter empathy development. Here, we demonstrated that pairs of mice that were simultaneously administered with a noxious stimulus (acetic acid) exhibited more pain‐related behaviors than when one of the pair was treated with a noxious stimulus. However, these differences disappeared when mice were separated from the dam 1 week earlier than the typical weaning age. Even when mice were alone, when treated with acetic acid, early weaning decreased their pain response. These results suggested that the disruption of mother–infant bonding through early weaning impairs pain contagion and modulates sensitivity to pain.