TNF-alpha/NF-kappaB/Snail pathway in cancer cell migration and invasion.

TNF-alpha/NF-kappaB/Snail pathway in cancer cell migration and invasion.
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DOI:
10.1038/sj.bjc.6605530
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发表时间:
2010-02-16
影响因子:
8.8
通讯作者:
--
中科院分区:
医学1区
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--
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肿瘤坏死因子-α (TNF-α) 是一种重要的炎症因子,在炎症与癌症之间建立复杂的联系中充当主开关。大量证据表明 TNF-α 在肿瘤增殖、迁移、侵袭和血管生成中发挥着关键作用。 TNF-α 作为肿瘤微环境的关键调节剂的功能已得到广泛认可。我们将强调TNF-α和核因子-κB通路对肿瘤细胞侵袭和转移的贡献。了解炎症介导的转移机制将揭示癌症预防和治疗的新治疗靶点。
Tumour necrosis factor-alpha (TNF-α) is an important inflammatory factor that acts as a master switch in establishing an intricate link between inflammation and cancer. A wide variety of evidence has pointed to a critical role of TNF-α in tumour proliferation, migration, invasion and angiogenesis. The function of TNF-α as a key regulator of the tumour microenvironment is well recognised. We will emphasise the contribution of TNF-α and the nuclear factor-κB pathway on tumour cell invasion and metastasis. Understanding the mechanisms underlying inflammation-mediated metastasis will reveal new therapeutic targets for cancer prevention and treatment.
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