TNF-alpha/NF-kappaB/Snail pathway in cancer cell migration and invasion.
TNF-alpha/NF-kappaB/Snail pathway in cancer cell migration and invasion.
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DOI:
10.1038/sj.bjc.6605530
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发表时间:
2010-02-16
影响因子:
8.8
通讯作者:
中科院分区:
文献类型:
--
作者:
Tumour necrosis factor-alpha (TNF-α) is an important inflammatory factor that acts as a master switch in establishing an intricate link between inflammation and cancer. A wide variety of evidence has pointed to a critical role of TNF-α in tumour proliferation, migration, invasion and angiogenesis. The function of TNF-α as a key regulator of the tumour microenvironment is well recognised. We will emphasise the contribution of TNF-α and the nuclear factor-κB pathway on tumour cell invasion and metastasis. Understanding the mechanisms underlying inflammation-mediated metastasis will reveal new therapeutic targets for cancer prevention and treatment.
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影响因子:
5.3
作者:
Carver, EA;Jiang, RL;Gridley, T
通讯作者:
Gridley, T
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Chuang, Mei-Jen;Sun, Kuang-Hui;Sun, Guang-Huan
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Sun, Guang-Huan
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Larue, L.
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Hughes CC
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IP, YT;PARK, RE;LEVINE, M
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LEVINE, M