Spike generator limits efficiency of information transfer in a retinal ganglion cell
Spike generator limits efficiency of information transfer in a retinal ganglion cell
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DOI：
10.1523/jneurosci.5346-03.2004
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发表时间：
2004-03-24
影响因子：
5.3
通讯作者：
Smith, RG
中科院分区：
文献类型：
--
作者：
Dhingra, NK;Smith, RG
视网膜神经节细胞传递给大脑的信号的质量对于感知很重要，因为它设置了最小的可检测刺激。神经节细胞通过选择性过滤器将分级电位转换为尖峰序列，但在此过程中会增加噪声。为了探讨信息如何有效地传递到棘波，我们测量了对比度检测阈值和增量阈值从梯度电位和棘波反应的轻快-短暂的神经节细胞。在体外37 ℃保存的完整哺乳动物视网膜中记录了对在细胞感受野中心闪烁的点的细胞内反应。在一个理想的观察者的单间隔强迫选择程序中测量了患者的耐受性。分级电位的检测阈值为1.5%对比度，而尖峰电位的检测阈值为3.8%。分级电位也使阈值增加约两倍，灰度级增加约60%。在低对比度下，增量阈值“下降”到检测阈值以下（
The quality of the signal a retinal ganglion cell transmits to the brain is important for preception because it sets the minimum detectable stimulus. The ganglion cell converts graded potentials into a spike train with a selective filter but in the process adds noise. To explore how efficiently information is transferred to spikes, we measured contrast detection threshold and increment threshold from graded potential and spike responses of brisk-transient ganglion cells. Intracellular responses to a spot flashed over the receptive field center of the cell were recorded in an intact mammalian retina maintained in vitro at 37degreesC. Thresholds were measured in a single-interval forced-choice procedure with an ideal observer. The graded potential gave a detection threshold of 1.5% contrast, whereas spikes gave 3.8%. The graded potential also gave increment thresholds approximately twofold lower and carried similar to60% more gray levels. Increment threshold "dipped" below the detection threshold at a low contrast (