MRI-compatible transurethral ultrasound system for the treatment of localized prostate cancer using rotational control
MRI-compatible transurethral ultrasound system for the treatment of localized prostate cancer using rotational control
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DOI：
10.1118/1.2841937
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发表时间：
2008-04-01
期刊：
影响因子：
3.8
通讯作者：
Bronskill, Michael J.
中科院分区：
文献类型：
--
作者：
Chopra, Rajiv;Baker, Nicole;Bronskill, Michael J.
磁共振成像（MRI）引导的经尿道超声治疗是一种潜在的微创治疗局限性前列腺癌，提供腺体内组织的精确靶向，治疗时间短，并能够量化治疗期间提供的空间加热模式。MRI引导的超声治疗中的一个重大挑战是能够在闭孔MR成像仪中操作的MRI兼容设备的设计和构造。我们描述了一个原型系统开发的MRI引导下经尿道超声治疗和表征的不同组件，包括加热器的设计，旋转电机和射频电子的性能。本研究中描述的超声加热施加器包含一个平面换能器，能够在组织的局部区域产生高强度超声能量。结果表明，加热施加器具有出色的MRI兼容性，能够在距离器械6 mm处获得精确的MR温度测量值。同时成像和旋转运动也可以在治疗过程中使用基于压电致动器的电机。使用原型系统在体模和犬模型中进行的加热实验验证了使用该系统同时进行MR成像和治疗输送的能力。可以使用在加热期间获取的MR温度测量来实现对治疗的实时控制，以实现前列腺内的热损伤的精确模式。已证明了在本研究中开发的系统在闭孔MR成像仪中用于MRI引导的经尿道超声治疗的技术可行性。(C)2008年美国医学物理学家协会。
Magnetic resonance imaging (MRI)-guided transurethral ultrasound therapy is a potential minimally invasive treatment for localized prostate cancer offering precise targeting of tissue within the gland, short treatment times, and the capability to quantify the spatial heating pattern delivered during therapy. A significant challenge in MRI-guided ultrasound therapy is the design and construction of MRI-compatible equipment capable of operation in a closed-bore MR imager. We describe a prototype system developed for MRI-guided transurethral ultrasound therapy and characterize the performance of the different components including the heating applicator design, rotational motor, and radio frequency electronics. The ultrasound heating applicator described in this study incorporates a planar transducer and is capable of producing high intensity ultrasound energy in a localized region of tissue. Results demonstrated that the heating applicator exhibits excellent MRI-compatibility, enabling precise MR temperature measurements to be acquired as close as 6 mm from the device. Simultaneous imaging and rotational motion was also possible during treatment using a motor based on piezoelectric actuators. Heating experiments performed in both phantoms and in a canine model with the prototype system verified the capability to perform simultaneous MR imaging and therapy delivery with this system. Real-time control over therapy using MR temperature measurements acquired during heating can be implemented to achieve precise patterns of thermal damage within the prostate gland. The technical feasibility of using the system developed in this study for MRI-guided transurethral ultrasound therapy in a closed-bore MR imager has been demonstrated. (C) 2008 American Association of Physicists in Medicine.