TOXICITY AND CARCINOGENICITY OF THE FUSARIUM-MONILIFORME METABOLITE, FUMONISIN-B1, IN RATS
TOXICITY AND CARCINOGENICITY OF THE FUSARIUM-MONILIFORME METABOLITE, FUMONISIN-B1, IN RATS
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DOI：
10.1093/carcin/12.7.1247
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发表时间：
1991-07-01
期刊：
影响因子：
4.7
通讯作者：
THIEL, PG
中科院分区：
文献类型：
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作者：
GELDERBLOM, WCA;KRIEK, NPJ;THIEL, PG
在26个月的时间内，将含有50 mg/kg纯（不< 90%）伏马菌素B1（FB 1）的半纯化玉米基饮食（从串珠镰刀菌菌株MRC 826的培养材料中分离）饲喂给一组25只大鼠。25只大鼠的对照组接受不含FB 1的相同饮食。在6、12、20和26个月时每组处死5只大鼠。肝脏是FB 1处理大鼠的主要靶器官，肝脏病理变化与先前报道的喂食F.第826章.从18个月开始死亡或处死的所有FB 1处理的大鼠都患有微结节和大结节性肝硬化，并且在肝门处具有大的可膨胀的胆管纤维化结节。在18至26个月期间被杀死和/或死亡的15只FB 1治疗大鼠中有10只（66%）发生了原发性肝细胞癌。转移到心脏，肺或肾脏中存在4个大鼠肝细胞癌。在任何对照大鼠中均未观察到肿瘤变化。在26个月后处死的FB 1处理大鼠的肾脏中存在慢性间质性肾炎。在FB 1处理的大鼠的食管、心脏或前胃中未观察到病变，这与将真菌培养物喂给大鼠时的先前发现相反。因此，FB 1可能是引起F.大鼠中的串珠状MRC 826。
A semi-purified corn-based diet containing 50 mg/kg of pure (not < 90%) fumonisin B1 (FB1), isolated from culture material of Fusarium moniliforme strain MRC 826, was fed to a group of 25 rats over a period of 26 months. A control group of 25 rats received the same diet without FB1. Five rats from each group were killed at 6, 12, 20 and 26 months. The liver was the main target organ in the FB1-treated rats and the hepatic pathological changes were identical to those previously reported in rats fed culture material of F. moniliforme MRC 826. All FB1-treated rats that died or were killed from 18 months onwards suffered from a micro- and macronodular cirhosis and had large expansile nodules of cholangiofibrosis at the hilus of the liver. Ten out of 15 FB1-treated rats (66%) that were killed and/or died between 18 and 26 months developed primary hepatocellular carcinoma. Metastases to the heart, lungs or kidneys were present in four of the rats with hepatocellular carcinoma. No neoplastic changes were observed in any of the control rats. Chronic interstitial nephritis was present in the kidneys of FB1-treated rats killed after 26 months. No lesions were observed in the esophagus, heart or forestomach of FB1-treated rats and this is contrary to previous findings when culture material of the fungus was fed to rats. It is concluded that FB1 is responsible for the hepatocarcinogenic and the hepatotoxic but not all the other toxic effects of culture material of F. moniliforme MRC 826 in rats.