A pilot six-week randomized controlled trial of oxytocin on social cognition and social skills in schizophrenia
A pilot six-week randomized controlled trial of oxytocin on social cognition and social skills in schizophrenia
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DOI：
10.1016/j.schres.2014.04.009
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发表时间：
2014-07-01
影响因子：
4.5
通讯作者：
Pedersen, Cort A.
中科院分区：
文献类型：
--
作者：
Gibson, Clare M.;Penn, David L.;Pedersen, Cort A.
目前的研究探讨了催产素是否可以改善社会认知和社会技能的个人精神分裂症使用六周，双盲设计。14名精神分裂症患者随机接受鼻内催产素或安慰剂溶液，并完成了一系列社会认知，社交技能和临床精神症状测量。结果显示，催产素组在恐惧识别、观点采择和阴性症状减少方面有所改善。这些初步研究结果表明，催产素治疗可能有助于改善精神分裂症的某些功能。精神分裂症的社会功能治疗的影响进行了讨论。由爱思唯尔公司出版
The current study explored whether oxytocin can improve social cognition and social skills in individuals with schizophrenia using a six-week, double-blind design. Fourteen participants with schizophrenia were randomized to receive either intranasal oxytocin or a placebo solution and completed a battery of social cognitive, social skills and clinical psychiatric symptom measures. Results showed within group improvements in fear recognition, perspective taking, and a reduction in negative symptoms in the oxytocin group. These preliminary findings indicate oxytocin treatment may help improve certain components of functioning in schizophrenia. Implications for the treatment of social functioning in schizophrenia are discussed. Published by Elsevier B.V.