Synthesis, characterization and drug release application of carbon nanotube-polymer nanosphere composites
Synthesis, characterization and drug release application of carbon nanotube-polymer nanosphere composites
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DOI：
10.1039/c3ra40997j
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发表时间：
2013-05
期刊：
影响因子：
3.9
通讯作者：
Haixia Wang;Jingfeng Li;Xiaoyuan Zhang;Zhaofei Ouyang;Qing Li;Zhiqiang Su;Gang Wei
中科院分区：
文献类型：
--
作者：
Haixia Wang;Jingfeng Li;Xiaoyuan Zhang;Zhaofei Ouyang;Qing Li;Zhiqiang Su;Gang Wei
我们在这里报告了一个成功的原位合成嵌段共聚物纳米球（CPNS）的侧壁上的多壁碳纳米管（MWCNTs），以创建功能性纳米材料。以聚环氧乙烷大分子单体和N-异丙基丙烯酰胺为单体，通过一锅法原子转移自由基聚合反应，沿着多壁碳纳米管（MWCNTs）制备了平均粒径约为100 nm的温敏型CPNS。采用FT-IR、1H NMR和拉曼光谱对合成的MWCNT-CPNS纳米复合材料进行了表征和确认。通过TGA测量MWCNTs上的接枝聚合物的量。通过TEM观察和鉴定了CPNS沿着壁的形成。此外，新创建的MWCNT-CPNS纳米复合材料被用作新型载体的控制抗癌药物（阿霉素）释放。结果表明，在所用热敏聚合物的低临界溶解温度（LCST）以下和以上，药物的释放量变化较大，因此所合成的MWCNT-CPNS纳米复合材料可作为一种潜在的药物递送和释放候选材料。我们期待基于多壁碳纳米管和CPNS的新型温敏纳米复合材料在体内靶向药物递送和释放方面有更广泛的应用。
We report here a successful in situ synthesis of block copolymer nanospheres (CPNS) on the side-walls of multi-walled carbon nanotubes (MWCNTs) to create functional nanomaterials. The thermo-sensitive CPNS with an average size of about 100 nm were created along MWCNTs by an one-pot atom transfer radical polymerization reaction with poly(ethylene oxide) macromonomer and N-isopropylacrylamide monomer. The synthesized MWCNT-CPNS nanocomposites were characterized and confirmed by FT-IR, 1H NMR, and Raman spectroscopy. The amount of grafted polymers on MWCNTs was measured by TGA. The formation of CPNS along the side-walls of MWCNTs was observed and identified by TEM. Furthermore, the newly-created MWCNT-CPNS nanocomposites were used as novel carriers for controlled anticancer drug (adriamycin) release. The obtained results indicate that the release amount of drugs varied greatly below and above the lower critical solution temperature (LCST) of the used thermo-sensitive polymer, and therefore the synthesized MWCNT-CPNS nanocomposites can be used as a kind of potential candidate for drug delivery and release. We expect the novel thermo-sensitive nanocomposites based on MWCNTs and CPNS will have wider applications in in vivo targeted drug delivery and release.