Frequency of EGFR mutations in 907 lung adenocarcioma patients of Indian ethnicity.
Frequency of EGFR mutations in 907 lung adenocarcioma patients of Indian ethnicity.
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DOI：
10.1371/journal.pone.0076164
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Dutt A
中科院分区：
文献类型：
--
作者：
Chougule A;Prabhash K;Noronha V;Joshi A;Thavamani A;Chandrani P;Upadhyay P;Utture S;Desai S;Jambhekar N;Dutt A
在过去的十年中，EGFR突变的发生率已被证明在不同种族之间存在差异。在北美和欧洲的发病率为10-15%，在非洲裔美国人中为19%，在包括中国人，韩国人和日本人在内的各种东亚系列中为20-30%。然而，印度EGFR突变的频率仍然很少探索。我们报告了907例印度裔非小细胞肺癌（NSCLC）患者中表皮生长因子受体（EGFR）突变的发生率为23%，而白种人为10-15%，东亚人为27-62%。在这项研究中，EGFR突变在从不吸烟者中更常见，29.4%，而吸烟者为15.3%。与其他人群一致，腺癌男性的突变率主要低于女性，发生率为32%。然而，与高加索人不同，腺癌从不吸烟女性的EGFR突变率与男性相当，表明可能从EGFR靶向治疗中获益的从不吸烟者缺乏性别偏倚。本研究对确立临床NSCLC患者常规EGFR突变诊断的相关性具有总体意义，并强调了采用EGFR抑制剂作为印度人群一线治疗的有效性。与高加索人和东亚人相比，印度人群中EGFR突变的中间频率使人想起中东人、中亚人和欧洲人对现代印度人群的遗传影响的祖先混合物，这可能赋予EGFR体细胞突变的差异易感性。
During the past decade, the incidence of EGFR mutation has been shown to vary across different ethnicities. It occurs at the rate of 10–15% in North Americans and Europeans, 19% in African-Americans, 20–30% in various East Asian series including Chinese, Koreans, and Japanese. Frequency of EGFR mutations in India however remains sparsely explored. We report 23% incidence of Epidermal growth factor receptor (EGFR) mutations in 907 Non small cell lung cancer (NSCLC) patients of Indian ethnicity, in contrast to 10–15% known in Caucasians and 27–62% among East Asians. In this study, EGFR mutations were found to be more common in never-smokers 29.4% as compared to smokers 15.3%. Consistent with other populations, mutation rates among adenocarcinoma-males were predominantly lower than females with 32% incidence. However unlike Caucasians, EGFR mutation rate among adenocarcinoma-never-smoker females were comparable to males suggesting lack of gender bias among never smokers likely to benefit from EGFR targeted therapy. This study has an overall implication for establishing relevance for routine EGFR mutation diagnostics for NSCLC patients in clinics and emphasizes effectiveness for adoption of EGFR inhibitors as the first line treatment among Indian population. The intermediate frequency of EGFR mutation among Indian population compared to Caucasians and East Asians is reminiscent of an ancestral admixture of genetic influence from Middle Easterners, Central Asians, and Europeans on modern- Indian population that may confer differential susceptibility to somatic mutations in EGFR.
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