Chisomicines A-C, Limonoids from Chisocheton ceramicus
Chisomicines A-C, Limonoids from Chisocheton ceramicus
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DOI：
10.1021/np200013g
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发表时间：
2011-05-01
影响因子：
5.1
通讯作者：
Morita, Hiroshi
中科院分区：
文献类型：
--
作者：
Najmuldeen, Ibrahim A.;Hadi, A. Hamid A.;Morita, Hiroshi
从蜡梅树皮中分离得到3个新的柠檬苦素类化合物，分别为Chisomicines A-C(1-3)。其结构经二维核磁共振、圆二色谱和X-射线分析确证。在高细胞存活率条件下，Chisomicine A(1)对脂多糖刺激的J774.1细胞无抑制作用，且呈剂量依赖性。
Three new limonoids, chisomicines A-C (1-3), have been isolated from the bark of Chisocheton ceramicus. Their structures were determined by 2D NMR, CD spectroscopic methods, and X-ray analysis. Chisomicine A (1) exhibited NO production inhibitory activity in J774.1 cells stimulated by LPS dose-dependently at high cell viability.