HABITUAL FISH CONSUMPTION, PLASMA PHOSPHOLIPID FATTY-ACIDS, AND SERUM-LIPIDS - THE TROMSO STUDY
HABITUAL FISH CONSUMPTION, PLASMA PHOSPHOLIPID FATTY-ACIDS, AND SERUM-LIPIDS - THE TROMSO STUDY
复制标题
DOI：
10.1093/ajcn/55.6.1126
复制
发表时间：
1992-06-01
影响因子：
7.1
通讯作者：
NORDOY, A
中科院分区：
文献类型：
--
作者：
BONAA, KH;BJERVE, KS;NORDOY, A
我们研究了152名男性和女性的习惯性鱼类消费频率、血浆磷脂脂肪酸、血脂和脂蛋白之间的横截面关系。从1盘/周开始的鱼类消费量与血浆n-3、n-6和n-9脂肪酸之间存在显著关联。血浆二十碳五烯酸（EPA; 20：5 n-3）比二十二碳六烯酸（DHA; 22：6 n-3）更能反映鱼类消费量。甘油三酯随鱼的摄入而降低（P < 0.05）。在控制人体测量学和生活方式因素的多变量分析中，EPA与甘油三酯呈负相关（P < 0.05），与高密度脂蛋白（HDL）胆固醇和载脂蛋白A-I呈正相关（均P < 0.001）。相反，DHA与甘油三酯无关，与HDL胆固醇和载脂蛋白A-I呈负相关（均P < 0.001）。血小板磷脂EPA（而非DHA）与甘油三酯和HDL-胆固醇浓度降低相关（均P < 0.05）。这项研究表明，长期少量摄入鱼类具有生物学效应，EPA和DHA与脂蛋白代谢的关系不同。
We examined the cross-sectional relationships between the frequency of habitual fish consumption, plasma phospholipid fatty acids, and serum lipids and lipoproteins in 152 men and women. There was a significant association between fish consumption starting from 1 dish/wk and plasma n-3, n-6, and n-9 fatty acids. Plasma eicosapentaenoic acid (EPA; 20:5n-3) reflected fish consumption to a greater extent than did docosahexaenoic acid (DHA; 22:6n-3). Triglycerides decreased (P < 0.05) with fish consumption. In multivariate analysis in which anthropometric and lifestyle factors were controlled for, EPA correlated inversely with triglycerides (P < 0.05) and positively with high-density-lipoprotein (HDL) cholesterol and apolipoprotein A-I (both P < 0.001). In contrast, DHA did not correlate with triglycerides and showed negative associations to HDL cholesterol and apolipoprotein A-I (both P < 0.001). Platelet phospholipid EPA, but not DHA, was associated with lower triglyceride and higher HDL-cholesterol concentrations (both P < 0.05). This study suggests that long-term intake of small amounts of fish has biological effects, and that EPA and DHA have divergent relations with lipoprotein metabolism.