Prevalence, Distribution, and Morphology of Thoracic Ossification of the Yellow Ligament in Japanese Results of CT-Based Cross-Sectional Study
Prevalence, Distribution, and Morphology of Thoracic Ossification of the Yellow Ligament in Japanese Results of CT-Based Cross-Sectional Study
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DOI：
10.1097/brs.0b013e31829e018b
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发表时间：
2013-09-01
期刊：
影响因子：
3
通讯作者：
Imai, Shinji
中科院分区：
文献类型：
--
作者：
Mori, Kanji;Kasahara, Toshiyuki;Imai, Shinji
研究设计。一项横断面研究。客观的。通过计算机断层扫描(CT)和文献复习，了解胸部黄韧带骨化症(OYL)的发病率、形态和分布。OYL的流行病学和病因尚不清楚。到目前为止，据我们所知，还没有研究通过CT对胸椎进行全面评估，以评估OYL在足够大的样本量和广泛的年龄分布中的患病率、分布和形态。本研究的研究对象为在我所接受胸部CT检查的肺部疾病患者。排除有胸椎手术史且年龄在15岁以下的患者。对胸廓OYL的患病率、分布和形态进行综述。共纳入3013例患者(女性1261例，男性1752例)，平均年龄65岁。1094名(428名女性和666名男性)患者(36%)有基于CT的OYL证据。单节段受累532例，多节段受累562例。统计分析表明，OYL在男性中的患病率显著高于男性(P=0.022)。其中中央型779个，位于椎板中央的蘑菇状骨化；非中央型1272个。胸腺OYL的分布形成两个峰，最高峰出现在T10-T11，次峰出现在T4-T5。有趣的是，OYL在30岁以后以一致的速度出现；然而，它的大小随着年龄的增加而增加。日本人胸部OYL的患病率为36%。有必要进一步研究OYL的临床表现与其大小和/或形态之间的关系。
Study Design. A cross-sectional study.Objective. To gain an insight for the prevalence, morphology, and distribution of thoracic ossification of the yellow ligament (OYL) by computed tomography (CT) and review of the literature.Summary of Background Data. The epidemiology and etiology of OYL remains obscure. To date, to the best of our knowledge, there is no study that comprehensively evaluated thoracic spine by CT to assess the prevalence, distribution, and morphology of OYL in a large enough sample size with wide age distribution.Methods. The participants of this study were the patients who have undergone chest CT for the examination of pulmonary diseases in our institute. The patients with previous thoracic spine surgery and younger than 15 years were excluded. Prevalence, distribution, and morphology of thoracic OYL were reviewed.Results. A total of 3013 patients (1261 females and 1752 males) with the mean age of 65 years were recruited. The CT-based evidence of OYL was noted in 1094 (428 females and 666 males) individuals (36%). Single-level involvement was noted in 532 cases, whereas 562 individuals presented multilevel involvement. Statistical analyses revealed that OYL was noted at a significantly higher rate among the males (P = 0.022). Of a total of 2051 OYLs, 779 central type OYLs, a mushroom-shaped ossification localized at the center of laminae, and 1272 noncentral type OYLs were noted. Distribution of the thoracic OYL formed 2 peaks with the highest and second highest peak found at T10-T11 and T4-T5, respectively. Interestingly, OYL is noted at consistent rates after the age of 30; however, its size increased in age-dependent manners.Conclusion. The prevalence of thoracic OYL in Japanese was 36%. A further study disclosing the association between clinical manifestations and size and/or morphology of OYL is warranted.