Validation of the Delayed Matching-to-Sample Task 48 (DMS48) in Elderly Chinese
Validation of the Delayed Matching-to-Sample Task 48 (DMS48) in Elderly Chinese
复制标题
延迟匹配样本任务 48 (DMS48) 在老年人中的验证
DOI：
10.3233/jad-170530
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发表时间：
2018-01-01
影响因子：
4
通讯作者：
Jia, Jianping
中科院分区：
文献类型：
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作者：
Feng, Xueyan;Zhou, Aihong;Jia, Jianping
背景：延迟匹配-样本任务48 （DMS48）是一种测量视觉识别记忆的简单工具，可有效识别白种人阿尔茨海默病（AD）的早期阶段。然而，中文的数据很少。目的：建立中国老年人DMS48的标准和最佳分界点。方法：在全国5个城市的7家记忆诊所进行横断面研究。DMS48应用于369名50岁及以上的中国人，其中138人认知正常[CN]， 112人因AD轻度认知障碍（MCI-A）， 119人轻度AD痴呆。调查了影响DMS48得分的人口因素，并考虑这些因素建立了规范。采用受试者工作特征（ROC）分析确定最佳分界点。结果：年龄对DMS48评分有影响（r = -0.36, p < 0.05），我们给出了DMS48的年龄分层规范数据。识别认知障碍（MCI-A和AD痴呆）对CN（敏感性97.80%，特异性89.13%）和MCI-A对CN（敏感性86.60%，特异性94.20%）的最佳截断点为42/43。39/40的临界值在区分AD痴呆和CN方面获得了良好的敏感性（100.00%）和特异性（94.90%）。50 ~ 59岁、60 ~ 69岁、70 ~ 79岁、80岁及以上的MCI-A最佳识别截断点分别为43/44、42/43、41/42和40/41（敏感性84.80%、特异性95.70%）。结论：本研究证明DMS48在中国老年人MCI-A筛查中具有良好的有效性。
Background: Delayed Matching-to-Sample Task 48 (DMS48), a brief tool measuring visual recognition memory, is valid to identify the early stage of Alzheimer's disease (AD) in Caucasians. However, little data is available in Chinese.Objective: To develop norms and optimal cutoff points for the DMS48 in Chinese elders.Methods: A cross-sectional study was conducted in seven memory clinics from five cities across China. DMS48 was applied to 369 Chinese aged 50 or older (138 cognitively normal [CN], 112 mild cognitive impairment due to AD (MCI-A), and 119 mild AD dementia). The demographic factors which influence DMS48 scores were investigated and the norms were established considering those factors. Receiver operating characteristic (ROC) analysis was used to determine the optimal cutoff points.Results: Age was shown to influence DMS48 scores (r = -0.36, p < 0.05), and we presented the age-stratified normative data for the DMS48. The optimal cutoff point is 42/43 for identifying cognitive impairment (MCI-A and AD dementia) against CN (sensitivity 97.80% and specificity 89.13%) and MCI-A against CN (sensitivity 86.60% and specificity 94.20%). A cutoff of 39/40 obtained good sensitivity (100.00%) and specificity (94.90%) in discriminating AD dementia from CN. The age-stratified optimal cutoff points for identifying MCI-A were 43/44 for individuals aged 50 to 59 years old, 42/43 for 60 to 69 years old, 41/42 for 70 to 79 years old, and 40/41 for 80 or older, respectively (sensitivity 84.80% and specificity 95.70%).Conclusion: This study proved that DMS48 is of good validation in screening MCI-A in elderly Chinese.