Object Representations in the Temporal Cortex of Monkeys and Humans as Revealed by Functional Magnetic Resonance Imaging
Object Representations in the Temporal Cortex of Monkeys and Humans as Revealed by Functional Magnetic Resonance Imaging
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DOI：
10.1152/jn.90657.2008
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发表时间：
2009-02-01
影响因子：
2.5
通讯作者：
Ungerleider, Leslie G.
中科院分区：
文献类型：
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作者：
Bell, Andrew H.;Hadj-Bouziane, Fadila;Ungerleider, Leslie G.
Bell AH，Hadj-Bouziane F，Frihauf JB，Tootell RB，Ungerleider LG.通过功能性磁共振成像揭示的猴子和人类颞叶皮层中的对象表征。神经生理学杂志101：688 - 700，2009年。首次发表于2008年12月3日; doi：10.1152/jn.90657.2008。越来越多的证据表明，与识别日常刺激相关的神经过程包括将这些刺激分类为有限数量的语义类别。这些刺激的神经表征如何在颞叶中组织仍然存在争议。在这里，我们使用功能性磁共振成像（fMRI），以确定相关的三个当前的假设对象表示在下颞（IT）皮层的猴子和人类：表示基于生命，语义类别，或视觉特征。受试者被呈现了面部，身体部位（有生命的刺激），物体和地方（无生命的刺激）的块图像，并使用多个重叠的对比来确定每个类别最具选择性的体素。刺激表示出现隔离根据语义关系。在这两个物种的离散区域选择性的有生命和无生命的刺激。这些区域可以进一步细分为针对各个类别进行选择的区域。值得注意的是，面部选择性区域与身体部位选择性区域相邻，物体选择性区域与位置选择性区域相邻。当猴子的类别选择性区域进行测试与块的单一样本，个体素表现出偏好视觉上不同的样本从同一类别和体素具有相似的偏好往往聚集在一起。我们的研究结果提供了一些新的观察方面的刺激表征是如何组织在IT皮层。此外，他们进一步支持的想法，复杂的刺激在IT皮层的表征组织成多个层次，包括语义和物理属性。
Bell AH, Hadj-Bouziane F, Frihauf JB, Tootell RB, Ungerleider LG. Object representations in the temporal cortex of monkeys and humans as revealed by functional magnetic resonance imaging. J Neurophysiol 101: 688-700, 2009. First published December 3, 2008; doi:10.1152/jn.90657.2008. Increasing evidence suggests that the neural processes associated with identifying everyday stimuli include the classification of those stimuli into a limited number of semantic categories. How the neural representations of these stimuli are organized in the temporal lobe remains under debate. Here we used functional magnetic resonance imaging (fMRI) to identify correlates for three current hypotheses concerning object representations in the inferior temporal (IT) cortex of monkeys and humans: representations based on animacy, semantic categories, or visual features. Subjects were presented with blocked images of faces, body parts (animate stimuli), objects, and places (inanimate stimuli), and multiple overlapping contrasts were used to identify the voxels most selective for each category. Stimulus representations appeared to segregate according to semantic relationships. Discrete regions selective for animate and inanimate stimuli were found in both species. These regions could be further subdivided into regions selective for individual categories. Notably, face-selective regions were contiguous with body-part-selective regions, and object-selective regions were contiguous with placeselective regions. When category-selective regions in monkeys were tested with blocks of single exemplars, individual voxels showed preferences for visually dissimilar exemplars from the same category and voxels with similar preferences tended to cluster together. Our results provide some novel observations with respect to how stimulus representations are organized in IT cortex. In addition, they further support the idea that representations of complex stimuli in IT cortex are organized into multiple hierarchical tiers, encompassing both semantic and physical properties.