Accuracy of radionuclide ventriculography for estimation of left ventricular volume changes and end-systolic pressure-volume relations.
Accuracy of radionuclide ventriculography for estimation of left ventricular volume changes and end-systolic pressure-volume relations.
复制标题
放射性核素心室造影估计左心室容量变化和收缩末期压力-容量关系的准确性。
DOI：
10.1016/s0735-1097(85)80310-7
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发表时间：
1985
影响因子：
24
通讯作者：
Friesinger,GC
中科院分区：
文献类型：
--
作者：
Kronenberg,MW;Parrish,MD;JenkinsJr,DW;Sandler,MP;Friesinger,GC
左心室收缩末期压力-容积关系的估计依赖于精确测量心室容积的微小变化。为了研究放射性核素脑室造影术的准确性，在对照期和注射苯肾上腺素使血压增加30毫米汞柱时，对7只狗进行了配对的放射性核素脑室造影术。通过输注阿托品保持心率不变。核素与心室造影术的相关性很好。个体左室容积r均值为0.96±0.03（±SD） （p = 0.001, n = 7），收缩期末期容积变化r均值为0.90±0.08 （n = 7，范围0.76 ~ 0.99）。在整个系列中，有33个收缩期末期体积变化，尽管体积变化平均仅为11.9±8.2 ml（范围0.3至38.1），但放射性核素-造影剂相关性同样很强（r = 0.89, p < 0.001, n = 33）。核素和心室造影术的收缩压-容积关系均为线性（r分别为0.98和0.97,n = 7）。核素脑室造影的平均斜率（2.9±1.4）低于造影剂脑室造影的平均斜率（4.8±1.7）（p = 0.004）；然而，斜率相关性良好（r = 0.81, n = 7, p = 0.026）。使用背景减法、衰减校正、两者都不使用或两者都使用来比较放射性核素-造影剂体积关系。通过每种方法，放射性核素心室造影都是有效的测量左心室容积的微小变化和确定收缩末期压力-容积关系。
Estimation of left ventricular end-systolic pressure-volume relations depends on the accurate measurement of small changes in ventricular volume. To study the accuracy of radionuclide ventriculography, paired radionuclide and contrast ventriculograms were obtained in seven dogs during a control period and when blood pressure was increased in increments of 30 mm Hg by phenylephrine infusion. The heart rate was held constant by atropine infusion.The correlation between radionuclide and contrast ventriculography was excellent. In the individual animals, the average r value for left ventricular volume was 0.96 ± 0.03 (± SD) (p = 0.001, n = 7) and the mean r value for end-systolic volume changes was 0.90 ± 0.08 (n = 7, range 0.76 to 0.99). For the entire series, there were 33 end-systolic volume changes, and there was an equally strong radionuclide-contrast correlation (r = 0.89, p < 0.001, n = 33), even though the volume changes averaged only 11.9 ± 8.2 ml (range 0.3 to 38.1).The systolic pressure-volume relations were linear for both radionuclide and contrast ventriculography (r = 0.98 and 0.97, respectively, n = 7). The mean slope for radionuclide ventriculography (2.9 ± 1.4) was lower than the mean slope for contrast ventriculography (4.8 ± 1.7) (p = 0.004); however, the slopes correlated well (r = 0.81, n = 7, p = 0.026).The radionuclide-contrast volume relation was compared using background subtraction, attenuation correction, neither of these or both. By each method, radionuclide ventriculography was valid for measuring small changes in left ventricular volume and for defining endsystolic pressure-volume relations.