Occupational exposure to high-level disinfectants and risk of miscarriage among nurses.
Occupational exposure to high-level disinfectants and risk of miscarriage among nurses.
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DOI：
10.1136/oemed-2020-107297
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发表时间：
2021-10
影响因子：
4.9
通讯作者：
Chavarro JE
中科院分区：
文献类型：
--
作者：
Ding M;Lawson C;Johnson C;Rich-Edwards J;Gaskins AJ;Boiano J;Henn S;Rocheleau C;Chavarro JE
研究护士职业暴露于高水平消毒剂（HLDs）与流产风险之间的关系。我们的研究包括参加护士健康研究3（NHS 3）（2010-2020）并在随访期间至少怀孕一次的女性。在基线时自我报告HLD的职业暴露。每六个月，研究人员会向参与者发送一份后续调查问卷，询问有关怀孕的详细信息。我们使用离散时间考克斯模型计算流产的风险比（HR）和95% CI（根据暴露于HLD）。我们的研究包括2579名护士，平均随访时间为5.6年（范围：1-9年），我们记录了3974例妊娠中的768例（19%）流产。与未暴露于HLD的女性相比，既往使用者流产的风险比（HR）为1.08（95% CI：0.87，1.34），HLD使用者为0.84（95% CI：0.68，1.04）。与没有HLD暴露的妇女相比，HLD的持续时间、频率和类型以及暴露对照的使用与流产风险无关。当仅限于使用HLD后12个月内发生的妊娠时，职业暴露于未指明类型的HLD与较高的流产风险显著相关（HR=1.78; 95% CI：1.08，2.93）。我们观察到职业性使用HLD与流产之间没有关联;除非我们仅限于评估基线暴露后12个月内发生的妊娠。鉴于观察性设计和有限的样本量，应谨慎解释结果。
To examine the association of occupational exposure to high-level disinfectants (HLDs) with risk of miscarriage among nurses. Our study included women who enrolled in the Nurses’ Health Study 3 (NHS3) (2010–2020) and had at least one pregnancy during follow up. Occupational exposure to HLDs was self-reported at baseline. Every six months, a follow-up questionnaire was sent to participants asking for detailed information on pregnancies. We used a discrete-time Cox model to calculate the hazard ratios (HRs) and 95% CIs of miscarriage according to exposure to HLDs. Our study included 2579 nurses with a median of 5.6 years of follow-up (range: 1–9 years), and we documented 768 (19%) cases of miscarriage among 3974 pregnancies. Compared to women with no HLD exposure, the hazard ratios (HRs) of miscarriage were 1.08 (95% CI: 0.87, 1.34) for past users, and 0.84 (95% CI: 0.68, 1.04) for HLD users. Compared to women with no HLD exposure, duration, frequency, and type of HLD and use of exposure controls were not associated with risk of miscarriage. When restricting to pregnancies that occurred within 12 months of HLD use, occupational exposure to unspecified types of HLD was significantly associated with higher risk of miscarriage (HR=1.78; 95% CI: 1.08, 2.93). We observed no associations between occupational use of HLDs and miscarriage; except when we restricted to pregnancies occurring within 12 months of assessed baseline exposure. Given the observational design and limited sample size, results should be interpreted cautiously.
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影响因子：
3
作者：
Cristofari-Marquand, Emmanuelle;Kacel, Myriam;Lehucher-Michel, Marie-Pascale
通讯作者：
Lehucher-Michel, Marie-Pascale
DOI：
10.1007/s00420-006-0163-y
发表时间：
2007-07-01
影响因子：
3
作者：
Gresie-Brusin, Daniela F.;Kielkowski, Danuta;Rees, David
通讯作者：
Rees, David
影响因子：
12.4
作者：
Di Stefano, F;Siriruttanapruk, S;Burge, PS
通讯作者：
Burge, PS
DOI：
10.1034/j.1600-0412.2000.079006471.x
发表时间：
2000-06-01
影响因子：
4.3
作者：
Kristensen, P;Irgens, LM
通讯作者：
Irgens, LM
影响因子：
4.5
作者：
Henn, Scott A.;Boiano, James M.;Steege, Andrea L.
通讯作者：
Steege, Andrea L.